Defining a master curve of abdominal aortic aneurysm growth and its potential utility of clinical management.
Defining a master curve of abdominal aortic aneurysm growth and its potential utility of clinical management.
复制标题
DOI：
10.1016/j.cmpb.2021.106256
复制
发表时间：
2021-09
影响因子：
6.1
通讯作者：
Baek S
中科院分区：
文献类型：
--
作者：
Akkoyun E;Gharahi H;Kwon ST;Zambrano BA;Rao A;Acar AC;Lee W;Baek S
腹主动脉瘤 (AAA) 的最大直径测量取决于 AAA 内的正交和轴向横截面或最大内接球体，在临床决策过程中发挥着重要作用。本研究旨在从纵向 CT 扫描中建立总共 21 个形态参数并分析它们的相关性。此外，这项工作探索了 AAA 生长的“主曲线”的存在，并测试了哪些参数有助于增强其临床应用的可预测性。回顾性获得 25 名韩国 AAA 患者的 106 张 CT 扫描图像。随后，我们计算了形态参数、生长率和成对相关性，并尝试使用非线性曲线拟合和最小二乘最小化来增强高风险动脉瘤生长的可预测性。指数 AAA 生长模型适合最大球形直径，作为所有参数中生长的最佳代表（r 方：0.94），并基于 95% 置信区间正确预测 16 次验证扫描中的 15 次。 AAA 体积扩张率与血栓积累率高度相关（r=0.75）。使用球体直径的指数生长模型提供了有关动脉瘤大小进展的有用信息，并能够在给定的监测期内进行 AAA 生长率外推。
The maximum diameter measurement of an abdominal aortic aneurysm (AAA), which depends on orthogonal and axial cross-sections or maximally inscribed spheres within the AAA, plays a significant role in the clinical decision making process. This study aims to build a total of 21 morphological parameters from longitudinal CT scans and analyze their correlations. Furthermore, this work explores the existence of a “master curve” of AAA growth, and tests which parameters serve to enhance its predictability for clinical use. 106 CT scan images from 25 Korean AAA patients were retrospectively obtained. We subsequently computed morphological parameters, growth rates, and pair-wise correlations, and attempted to enhance the predictability of the growth for high-risk aneurysms using non-linear curve fitting and least-square minimization. An exponential AAA growth model was fitted to the maximum spherical diameter, as the best representative of the growth among all parameters (r-square: 0.94) and correctly predicted to 15 of 16 validation scans based on a 95% confidence interval. AAA volume expansion rates were highly correlated (r=0.75) with thrombus accumulation rates. The exponential growth model using spherical diameter provides useful information about progression of aneurysm size and enables AAA growth rate extrapolation during a given surveillance period.
登录
查看更多内容
DOI：
10.1016/j.ejvs.2005.10.007
发表时间：
2006-03-01
影响因子：
5.7
作者：
de Céniga, MV;Gómez, R;Barba, A
通讯作者：
Barba, A
影响因子：
158.5
作者：
Lederle, FA;Wilson, SE;Bandyk, D
通讯作者：
Bandyk, D
DOI：
10.1016/j.ejvs.2005.10.032
发表时间：
2006-03-01
影响因子：
5.7
作者：
Golledge, J;Muller, J;Norman, PE
通讯作者：
Norman, PE
影响因子：
1.5
作者：
Kristmundsson, Thorarinn;Dias, Nuno;Sonesson, Bjorn
通讯作者：
Sonesson, Bjorn
影响因子：
4.3
作者：
Skibba, Afshin A.;Evans, James R.;Rush, Daniel S.
通讯作者：
Rush, Daniel S.