Overview of animal models of obesity.
Overview of animal models of obesity.
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DOI：
10.1002/0471141755.ph0561s58
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发表时间：
2012-09
影响因子：
--
通讯作者：
Woods, Stephen C
中科院分区：
文献类型：
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作者：
Lutz, Thomas A;Woods, Stephen C
本文就目前研究中使用的肥胖动物模型作一综述。我们专注于更常用的模型，因为有太多新创建的模型需要考虑，特别是那些由选择性分子遗传方法修饰特定细胞群体中的一个或多个基因引起的模型。此外，我们将不讨论诱导型转基因动物（诱导敲除或敲入）的产生和使用，即使它们与传统转基因动物相比通常具有显著的优势;可以最小化动物发育期间遗传修饰的影响。这些动物模型的数量实在太多，本章无法涵盖。
This is a review of animal models of obesity currently used in research. We have focused upon more commonly utilized models since there are far too many newly created models to consider, especially those caused by selective molecular genetic approaches modifying one or more genes in specific populations of cells. Further, we will not discuss the generation and use of inducible transgenic animals (induced knock-out or knock-in) even though they often bear significant advantages compared to traditional transgenic animals; influences of the genetic modification during the development of the animals can be minimized. The number of these animal models is simply too large to be covered in this chapter.