Dynamically Arranging Gold Nanoparticles on DNA Origami for Molecular Logic Gates
Dynamically Arranging Gold Nanoparticles on DNA Origami for Molecular Logic Gates
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在 DNA 折纸上动态排列金纳米粒子用于分子逻辑门
DOI：
10.1021/acsami.6b04992
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发表时间：
2016
影响因子：
9.5
通讯作者：
Zhang Cheng
中科院分区：
文献类型：
--
作者：
Yang Jing;Song Zhichao;Liu Shi;Zhang Qiang;Zhang Cheng
在分子工程中，DNA分子由于其精确的结构控制和复杂的可编程性而被广泛研究。最近的研究表明，DNA折纸的多功能性和可预测性使其成为构建纳米器件的绝佳平台。在这项研究中，我们开发了一种链置换策略，选择性地和动态地释放特定的金纳米粒子（AuNPs）的矩形DNA折纸。基于该策略建立了一组DNA逻辑门（“或”、“与”和“三输入多数门”），通过AuNPs和DNA折纸之间的拆解来识别计算结果。利用凝胶电泳和透射电子显微镜等实验手段对计算结果进行了检测。这种方法可以用来组装更复杂的纳米系统，并可能在分子工程中有潜在的应用。
In molecular engineering, DNA molecules have been extensively studied owing to their capacity for accurate structural control and complex programmability. Recent studies have shown that the versatility and predictability of DNA origami make it an excellent platform for constructing nanodevices. In this study, we developed a strand-displacing strategy to selectively and dynamically release specific gold nanoparticles (AuNPs) on a rectangular DNA origami. A set of DNA logic gates (“OR”, “AND”, and “three-input majority gate”) were established based on this strategy, in which computing results were identified by disassembly between the AuNPs and DNA origami. The computing results were detected using experimental approaches such as gel electrophoresis and transmission electron microscopy (TEM). This method can be used to assemble more complex nanosystems and may have potential applications for molecular engineering.