Molecular and cellular insights into T cell exhaustion.
Molecular and cellular insights into T cell exhaustion.
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DOI：
10.1038/nri3862
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Kurachi M
中科院分区：
文献类型：
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作者：
Wherry EJ;Kurachi M
在慢性感染和癌症中，T细胞暴露于持续的抗原和/或炎症信号。这种情况通常与T细胞功能的恶化有关：一种称为“衰竭”的状态。耗尽的T细胞失去强大的效应子功能，表达多种抑制性受体，并由改变的转录程序定义。T细胞耗竭通常与持续感染和肿瘤的无效控制有关，但耗竭的T细胞的恢复可以重振免疫力。在这里，我们回顾了最近的进展，提供了一个更清晰的分子理解T细胞耗竭，并揭示了新的治疗目标，持续感染和癌症。
In chronic infections and cancer, T cells are exposed to persistent antigen and/or inflammatory signals. This scenario is often associated with the deterioration of T cell function: a state called ‘exhaustion’. Exhausted T cells lose robust effector functions, express multiple inhibitory receptors and are defined by an altered transcriptional programme. T cell exhaustion is often associated with inefficient control of persisting infections and tumours, but revitalization of exhausted T cells can reinvigorate immunity. Here, we review recent advances that provide a clearer molecular understanding of T cell exhaustion and reveal new therapeutic targets for persisting infections and cancer.