Co-occurrence of motor problems and autistic symptoms in attention-deficit/hyperactivity disorder
Co-occurrence of motor problems and autistic symptoms in attention-deficit/hyperactivity disorder
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DOI：
10.1097/chi.0b013e31816bff88
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发表时间：
2008-06-01
影响因子：
13.3
通讯作者：
Todd, Richard D.
中科院分区：
文献类型：
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作者：
Reiersen, Angela M.;Constantino, John N.;Todd, Richard D.
目的：探讨伴和不伴注意缺陷多动障碍(ADHD)儿童的父母报告的运动问题与临床上显著的自闭症症状之间的关系。方法：受试者为来自ADHD流行病学研究的男性(n=521)和女性(n=330)双胞胎，年龄7-19岁，使用儿童行为检查表和半结构精神病学诊断访谈进行评估。在参与访谈的1,647人中，62%的人收回了父母评定的社会反应性问卷。排除数据不完整或有精神发育迟滞证据的受试者后，851名受试者(52%)可用于本研究分析。每个受试者根据DSM-IVADHD亚型进行分类，并根据DSM-IVADHD症状的潜在类别分析将其分配到7个人群定义的ADHD亚型中的一个。在每个ADHD亚型中，我们研究了儿童行为检查表、运动问题认可和社会反应性量表上自闭症症状升高之间的关系。结果：运动问题和高水平的自闭症特征在混合型ADHD患者中最为常见。在每个临床相关的DSM-IV和潜伏期ADHD亚型中，运动问题和ADHD合并的个体比仅有ADHD的个体更有可能具有高水平的自闭症特征。结论：患有ADHD和父母报告的运动协调缺陷的儿童自闭症症状水平升高。可能需要有针对性的治疗和预防干预措施。应修订DSM-IVADHD的排除标准，以反映这些以人群为基础的发现。
Objective: To investigate the relation between parent reports of motor problems and clinically significant autistic symptoms in children with and without attention-deficit/hyperactivity disorder (ADHD). Method: Subjects were male (n = 521) and female (n = 330) twins from an epidemiological study of ADHD, ages 7 to 19 years at assessment using the Child Behavior Checklist and semistructured psychiatric diagnostic interviews. Parent-rated Social Responsiveness Scale questionnaires were returned for 62% of 1,647 individuals who participated in interviews. After exclusion of subjects with incomplete data or evidence of mental retardation, 851 subjects (52%) were available for the present study analysis. Each subject was classified by DSM-IVADHD subtype and assigned to one of seven population-defined ADHD subtypes based on latent class analysis of DSM-IVADHD symptoms. Within each ADHD subtype, we examined the relation between Child Behavior Checklist motor problem endorsement and elevated autistic symptoms on the Social Responsiveness Scale. Results: Motor problems and high levels of autistic traits were most common in individuals with combined-type ADHD. Within each of the clinically relevant DSM-IV and latent class ADHD subtypes, individuals with the combination of motor problems and ADHD were more likely to have high levels of autistic traits than those with ADHD alone. Conclusions: Children with the combination of ADHD and parent-reported motor coordination deficits have elevated levels of autistic symptoms. Targeted treatment and prevention interventions may be warranted. The exclusion criteria for DSM-IVADHD should be revised to reflect these population-based findings.