Dietary intake of iron, heme-iron and magnesium and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort
Dietary intake of iron, heme-iron and magnesium and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort
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DOI：
10.1002/ijc.27547
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发表时间：
2012-10-01
影响因子：
6.4
通讯作者：
Bueno-de-Mesquita, Bas
中科院分区：
文献类型：
--
作者：
Molina-Montes, Esther;Wark, Petra A.;Bueno-de-Mesquita, Bas
一些研究支持膳食镁对2型糖尿病的保护作用，但对铁的有害作用。由于糖尿病与胰腺癌有关，这些营养素的摄入也可能与这种癌症有关。我们在欧洲癌症与营养前瞻性研究（EPIC）队列中研究了膳食中镁、总铁和血红素铁摄入量与胰腺癌风险之间的关系。在1992年至2000年期间招募的142 203名男子和334 999名妇女共被包括在内。经过平均11.3年的随访，396名男性和469名女性患上了外分泌胰腺癌。采用考克斯回归法，按年龄和中心分层，并校正能量摄入、吸烟状况、身高、体重和自我报告的糖尿病状况，获得风险比和95%置信区间（CI）。镁、总铁和血红素铁的摄入均与胰腺癌风险无关。在分层分析中，观察到超重男性（体重指数≥ 25 kg/m2）与镁（HR/100 mg/天增加= 0.79，95% CI = 0.631.01）之间存在临界负相关，尽管使用校准摄入量时不太明显。在女性吸烟者中，血红素铁摄入量越高，胰腺癌风险越高（HR每增加1 mg/天= 1.38，95% CI = 1.101.74）。校准后，该风险显著增加至2.5倍（95% CI = 1.225.28）。总的来说，在随访期间，膳食镁、总铁和血红素铁与胰腺癌风险无关。我们观察到血红素铁与女性吸烟者胰腺癌风险增加有关，这一观察结果值得在其他研究人群中重复。
Several studies support a protective effect of dietary magnesium against type 2 diabetes, but a harmful effect for iron. As diabetes has been linked to pancreatic cancer, intake of these nutrients may be also associated with this cancer. We examined the association between dietary intake of magnesium, total iron and heme-iron and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In total, 142,203 men and 334,999 women, recruited between 1992 and 2000, were included. After an average follow-up of 11.3 years, 396 men and 469 women developed exocrine pancreatic cancer. Hazard ratios and 95% confidence intervals (CIs) were obtained using Cox regression stratified by age and center, and adjusted for energy intake, smoking status, height, weight, and self-reported diabetes status. Neither intake of magnesium, total iron nor heme-iron was associated with pancreatic cancer risk. In stratified analyses, a borderline inverse association was observed among overweight men (body mass index, =25 kg/m2) with magnesium (HRper 100 mg/day increase = 0.79, 95% CI = 0.631.01) although this was less apparent using calibrated intake. In female smokers, a higher intake of heme-iron was associated with a higher pancreatic cancer risk (HR per 1 mg/day increase = 1.38, 95% CI = 1.101.74). After calibration, this risk increased significantly to 2.5-fold (95% CI = 1.225.28). Overall, dietary magnesium, total iron and heme-iron were not associated with pancreatic cancer risk during the follow-up period. Our observation that heme-iron was associated with increased pancreatic cancer risk in female smokers warrants replication in additional study populations.