Successful outcome of liver transplantation in a patient with hepatitis C and common variable immune deficiency
Successful outcome of liver transplantation in a patient with hepatitis C and common variable immune deficiency
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DOI：
10.1111/j.1432-2277.2002.tb00183.x
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发表时间：
2002-07-01
影响因子：
3.1
通讯作者：
Mutimer, D
中科院分区：
文献类型：
--
作者：
Gow, PJ;Mutimer, D
一名患有常见变异性免疫缺陷的 43 岁男性因丙型肝炎病毒 (HCV) 引起的肝硬化接受了肝移植。 HCV 是从一批受污染的免疫球蛋白中获得的。他在感染该病毒后三年内出现肝硬化，然后出现肝功能衰竭，需要进行肝移植。移植后的过程并不复杂。移植后五个月，他出现肝功能衰竭，组织学表现为严重胆汁淤积性肝炎。取消免疫抑制导致肝功能衰竭恢复。还观察到 HCV 从血清中清除，并且在随访期间持续清除（尽管随后重新引入低剂量免疫抑制）。移植后患者已存活 5 年多，状况良好。他的移植后病程因丙型肝炎病毒的侵袭性复发和清除而引人注目。
A 43-year-old man with common variable immune deficiency underwent liver transplantation for cirrhosis caused by hepatitis C virus (HCV). HCV had been acquired from a contaminated batch of immunoglobulin. He developed cirrhosis within 3 years of infection with the virus, then liver failure requiring liver transplantation. The immediate post-transplant course was uncomplicated. Five months after transplantation he developed liver failure, and the histological appearances were those of severe cholestatic hepatitis. Withdrawal of immunosuppression resulted in recovery from liver failure. Clearance of the HCV from serum was also observed and has been sustained during follow-up (despite the subsequent reintroduction of low-dose immunosuppression). The patient is alive and well more than 5 years after transplantation. His post-transplant course has been remarkable for the aggressive recurrence then clearance of the HCV.