The importance of prostaglandin synthesis for the initiation of blastocyst implantation in the hamster.
The importance of prostaglandin synthesis for the initiation of blastocyst implantation in the hamster.
复制标题
前列腺素合成对于仓鼠囊胚植入启动的重要性。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
T. Kennedy
中科院分区：
文献类型：
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作者：
C. Evans;T. Kennedy
在仓鼠中，伊文思蓝染料摄取增加的局部区域（代表胚泡着床的第一个子宫体征）具有增加的PGE浓度，并且通过用PG合成抑制剂吲哚美辛处理来防止其在第4天的出现。吲哚美辛给药未终止妊娠：第5、7、10和16天妊娠动物的比例未受影响，尽管这些动物的胎仔死亡率略高。吲哚美辛处理导致第5天伊文思蓝部位和第10天着床部位的重量降低，妊娠持续时间略微增加，表明着床延迟。这种延迟不是由于循环孕酮水平或子宫血液供应的变化。PG合成抑制剂，吲哚美辛和甲氰尿酸降低子宫PG浓度，并防止出现伊文思蓝网站在卵巢切除孕仓鼠与孕酮治疗。这表明，前列腺素可能是介导的子宫伊文思蓝反应，在仓鼠植入前。
In hamsters, localized areas of increased uptake of Evans Blue dye, representing the first uterine sign of blastocyst implantation, had an increase concentration of PGE and their appearance on Day 4 was prevented by treatment with indomethacin, an inhibitor of PG synthesis. Indomethacin treatment did not terminate pregnancy: the proportion of animals pregnant on Days 5, 7, 10 and 16 was not affected, although fetal mortality was slightly greater in these animals. Indomethacin treatment caused a decrease in the weights of Evans Blue sites on Day 5 and implantation swellings on Day 10, and the duration of gestation was slightly increased, indicating that implantation had been delayed. This delay did not result from changes of circulating progesterone levels or uterine blood supply. The PG synthesis inhibitors, indomethacin and meclofenamic acid reduced uterine PG concentrations and prevented the appearance of Evans Blue sites in ovariectomized pregnant hamsters treated with progesterone. It is suggested that PGs may be mediators in the uterine Evans Blue response which precedes implantation in the hamster.