The effects of social status on biological aging as measured by white-blood-cell telomere length
The effects of social status on biological aging as measured by white-blood-cell telomere length
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DOI：
10.1111/j.1474-9726.2006.00222.x
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发表时间：
2006-10-01
期刊：
影响因子：
7.8
通讯作者：
Spector, T. D.
中科院分区：
文献类型：
--
作者：
Cherkas, L. F.;Aviv, A.;Spector, T. D.
低社会经济地位（SES）与预期寿命缩短有关，但其对衰老的影响尚不清楚。白细胞（WBC）端粒磨损率可能是人类衰老的生物学指标。我们检验了SES与端粒磨损相关的假设，该假设独立于影响衰老过程的已知风险因素。我们研究了1552对女性双胞胎。从每对双胞胎中采集静脉血样，并分离WBC用于提取DNA。测量末端限制性片段长度（TRFL）。调查对象的职业、文化程度、经济收入、吸烟、运动、身高和体重。标准多元线性回归和多变量方差分析测试SES和TRFL之间的关联，调整协变量。对一个子集进行不一致双胞胎分析以验证结果。WBC端粒长度高度可变，但在SES较低的组中显著较短。非手动和手动SES组之间TRFL的平均差异为163.2个碱基对（bp），其中22.9 bp（相似于14%）由体重指数、吸烟和运动引起。比较TRFL在17个最不和谐的SES双胞胎对证实了这种差异。除了吸烟、肥胖和缺乏锻炼的有害影响外，低SES似乎对端粒长度有影响。
Low socio-economic status (SES) is associated with a shortened life expectancy, but its effect on aging is unknown. The rate of white-blood-cell (WBC) telomere attrition may be a biological indicator of human aging. We tested the hypothesis that SES is associated with telomere attrition independent of known risk factors influencing the aging process. We studied 1552 female twins. A venous blood sample was taken from each twin and isolated WBCs used for extraction of DNA. Terminal restriction fragment length (TRFL) was measured. Questionnaire data were collected on occupation, education, income, smoking, exercise, height and weight. Standard multiple linear regression and multivariate analyses of variance tested for associations between SES and TRFL, adjusting for covariates. A discordant twin analysis was conducted on a subset to verify findings. WBC telomere length was highly variable but significantly shorter in lower SES groups. The mean difference in TRFL between nonmanual and manual SES groups was 163.2 base pairs (bp) of which 22.9 bp (similar to 14%) was accounted for by body mass index, smoking and exercise. Comparison of TRFL in the 17 most discordant SES twin pairs confirmed this difference. Low SES, in addition to the harmful effects of smoking, obesity and lack of exercise, appears to have an impact on telomere length.