Pulmonary Angiography with Iopamidol and Renografin 76 in Normal and Pulmonary Hypertensive Dogs
Pulmonary Angiography with Iopamidol and Renografin 76 in Normal and Pulmonary Hypertensive Dogs
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使用碘帕醇和 Renografin 76 对正常和肺动脉高压犬进行肺血管造影
DOI：
10.1177/028418518302400513
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发表时间：
1983
期刊：
影响因子：
1.3
通讯作者：
J. Rommel
中科院分区：
文献类型：
--
作者：
W. M. Thompson;S. R. Mills;M. Bates;L. Hedlund;J. Rommel
比较了使用标准离子制剂泛影酸盐 (Renografin 76) 和新型非离子制剂碘帕醇进行肺血管造影时产生的心血管反应。对 9 只狗进行了评估，同时使用室内空气和 10% O2 进行通气，肺动脉压显着升高。与生理盐水相比，碘帕醇对平均主动脉压和肺动脉压产生相似的变化（变化小于 20%）。然而，与生理盐水或碘帕醇相比，Renografin 76 显着提高平均肺动脉压（增加 41%）和降低平均主动脉压（减少 40%）（p 小于 0.01）。对于使用室内空气和氧气进行通风的狗来说，这些结果是相似的。结果表明，碘帕醇具有更好的耐受性，因此是比泛影酸盐更安全的肺血管造影造影剂。
The cardiovascular response produced during pulmonary angiography performed with the standard ionic agent diatrizoate (Renografin 76) and a new non-ionic agent iopamidol was compared. Nine dogs were evaluated while ventilated on room air and on 10% O2 which significantly elevated pulmonary arterial pressure. Iopamidol produced similar changes in mean aortic and pulmonary arterial pressures compared with normal saline (less than 20% change). Renografin 76, however, produced a significantly greater elevation in mean pulmonary arterial pressure (a 41% increase) and depression in mean aortic pressure (a 40% reduction) than either saline or iopamidol (p less than 0.01). These results were similar for dogs being ventilated with room air and oxygen. The results indicate that iopamidol should be better tolerated and therefore a safer contrast agent for pulmonary angiography than diatrizoate.