In Vivo Visualized Endolymphatic Hydrops and Inner Ear Functions in Patients With Electrocochleographically Confirmed Meniere's Disease
In Vivo Visualized Endolymphatic Hydrops and Inner Ear Functions in Patients With Electrocochleographically Confirmed Meniere's Disease
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DOI：
10.1097/mao.0b013e31825d9a95
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发表时间：
2012-08-01
影响因子：
2.1
通讯作者：
Krause, Eike
中科院分区：
文献类型：
--
作者：
Guerkov, Robert;Flatz, Wilhelm;Krause, Eike
目的：研究磁共振（MR）成像在体内检测到的内淋巴积水程度与确诊梅尼埃病患者的听觉和前庭功能之间的相关性。研究设计：前瞻性观察研究。设置：平衡障碍三级转诊中心。受试者和方法：在这项前瞻性研究中，根据美国耳鼻喉科协会，41例符合明确单侧梅尼埃病标准的患者-包括接受过头颈部手术的患者以及耳蜗电图显示总和电位与动作电位比值大于0.4的患者。使用3D反转恢复快速自旋回波序列对内耳进行鼓室内对比增强3 T MR成像。内淋巴积水的程度在耳蜗中以Likert量表（0-3）分级，在前庭中以前庭内淋巴空间比分级。结果：听力损失程度和病程与耳蜗积水有显著相关性（r = 0.85; r = 0.34）。球囊功能障碍与前庭积水显著相关（r = -0.47）。水平半规管麻痹与前庭积水无明显相关性。结论：经临床和耳蜗电图证实的梅尼埃病患者，MR形态学积水的严重程度与听功能和球囊功能损害显著相关。
Objective: To study the correlation between the degree of endolymphatic hydrops as detected in vivo by magnetic resonance (MR) imaging and the auditory and vestibular function in patients with definite Meniere's disease.Study Design: Prospective observational study.Setting: Tertiary referral center for balance disorders.Subjects and Methods: In this prospective study, 41 patients who fulfilled the criteria for definite unilateral Meniere's disease according to the American Association of Otolaryngology-Head and Neck Surgery and who showed a summating potential-to-action potential ratio of greater than 0.4 on electrocochleography were included. Intratympanic contrast-enhanced 3 Tesla MR imaging of the inner ear was performed using a 3D Inversion Recovery Turbo Spin Echo sequence. The degree of endolymphatic hydrops was graded on a Likert scale (0-3) in the cochlea and by vestibular endolymph space ratio in the vestibulum. The degree of hydrops was then analyzed with respect to its correlation with audiometric hearing levels, interaural amplitude ratios of vestibular evoked myogenic potentials, degree of horizontal semicircular canal paresis on caloric irrigation, and disease duration.Results: The degree of hearing loss and the disease duration correlated significantly with cochlear hydrops (r = 0.85; r = 0.34). Sacculus dysfunction was significantly correlated with vestibular hydrops (r = -0.47). There was no significant correlation between horizontal semicircular canal paresis and vestibular hydrops.Conclusion: In patients with clinically and electrocochleographically confirmed definite Meniere's disease, the degree of MR morphological hydrops severity correlates significantly with impairment of hearing function and sacculus function.