Beta-band oscillations in the supplementary motor cortex are modulated by levodopa and associated with functional activity in the basal ganglia.
Beta-band oscillations in the supplementary motor cortex are modulated by levodopa and associated with functional activity in the basal ganglia.
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DOI：
10.1016/j.nicl.2018.05.021
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Vaillancourt DE
中科院分区：
文献类型：
--
作者：
Chung JW;Burciu RG;Ofori E;Coombes SA;Christou EA;Okun MS;Hess CW;Vaillancourt DE
我们研究了急性左旋多巴给药对帕金森病（PD）运动相关的皮层振荡和运动速度的影响。PD患者和年龄、性别匹配的健康对照尽可能快速、准确地进行弹道上肢弯曲运动，同时用高密度脑电图记录皮质振荡。停用药物的患者也使用基于任务的功能磁共振成像（fMRI）进行研究，使用力控制范式。计算了手对侧壳核和丘脑下核（STN）在力控制任务中功能活动的信号变化百分比。我们发现，与对照组相比，PD停药患者在辅助运动区（SMA）有夸张的运动相关β带（13-30 Hz）不同步。在PD中，β波段的光谱功率与运动速度相关。在急性左旋多巴剂量后，我们观察到PD患者SMA的β带不同步减少，并与运动速度增加和激动剂肌肉活动电压增加有关。此外，通过fMRI，我们发现停药状态下壳核和STN的功能活动与PD的SMA皮层振荡对左旋多巴的反应程度有关。总的来说，这些发现首次直接评估了PD患者在运动弹道阶段与运动相关的皮层振荡与运动速度的关系，并证明了基底神经节通路的功能性脑活动与多巴胺能药物对运动期间皮层神经元振荡的影响有关。急性左旋多巴减少了SMA的β -带不同步，同时提高了运动速度和肌肉活动。运动时β带皮层活动与上肢运动速度呈正相关。基底神经节功能磁共振成像预测左旋多巴对β带皮层活动的反应。
We investigated the effect of acute levodopa administration on movement-related cortical oscillations and movement velocity in Parkinson's disease (PD). Patients with PD on and off medication and age- and sex-matched healthy controls performed a ballistic upper limb flexion movement as fast and accurately as possible while cortical oscillations were recorded with high-density electroencephalography. Patients off medication were also studied using task-based functional magnetic resonance imaging (fMRI) using a force control paradigm. Percent signal change of functional activity during the force control task was calculated for the putamen and subthalamic nucleus (STN) contralateral to the hand tested. We found that patients with PD off medication had an exaggerated movement-related beta-band (13–30 Hz) desynchronization in the supplementary motor area (SMA) compared to controls. In PD, spectral power in the beta-band was correlated with movement velocity. Following an acute dose of levodopa, we observed that the beta-band desynchronization in the SMA was reduced in PD, and was associated with increased movement velocity and increased voltage of agonist muscle activity. Further, using fMRI we found that the functional activity in the putamen and STN in the off medication state, was related to how responsive that cortical oscillations in the SMA of PD were to levodopa. Collectively, these findings provide the first direct evaluation of how movement-related cortical oscillations relate to movement velocity during the ballistic phase of movement in PD and demonstrate that functional brain activity in the basal ganglia pathways relate to the effects of dopaminergic medication on cortical neuronal oscillations during movement. Acute levodopa decreased beta-band desynchronization in the SMA, while improving movement velocity and muscle activity. Beta-band cortical activity during movement is positively correlated with upper limb movement velocity. fMRI in basal ganglia predicted the response of beta-band cortical activity to levodopa.
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DOI：
10.1016/j.nicl.2017.02.010
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Heinrichs-Graham E;Santamaria PM;Gendelman HE;Wilson TW
通讯作者：
Wilson TW
影响因子：
9.9
作者：
Grafton, ST;Turner, RS;Crutcher, M
通讯作者：
Crutcher, M
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.3
作者：
Brinkman, Loek;Stolk, Arjen;Toni, Ivan
通讯作者：
Toni, Ivan
影响因子：
29.3
作者：
GOLDBERG, G
通讯作者：
GOLDBERG, G