Age-related changes in pancreatic elasticity: When should we be concerned about their effect on strain elastography?
Age-related changes in pancreatic elasticity: When should we be concerned about their effect on strain elastography?
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DOI：
10.1016/j.ultras.2016.03.018
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发表时间：
2016-07-01
期刊：
影响因子：
4.2
通讯作者：
Goto, Hidemi
中科院分区：
文献类型：
--
作者：
Chantarojanasiri, Tanyaporn;Hirooka, Yoshiki;Goto, Hidemi
背景：超声应变弹性成像是评估胰腺病变的有用方法之一。在衰老过程中，胰腺实质发生一些变化，可能会干扰超声图像的解释。我们使用经腹部超声应变弹性成像技术，在没有已知胰腺疾病的受试者中研究了与年龄相关的胰腺弹性变化。 方法：这项研究是在学术医疗中心名古屋大学医院进行的，包括 102 名年龄 20-85 岁（平均 58.6 +/- 17.5）的受试者（66 名女性和 39 名男性），他们接受了经腹部超声检查以筛查和随访非胰腺疾病。对胰腺进行应变弹性成像，并对结果进行定量应变直方图分析。评估了年龄与四个弹性图参数（平均值、标准差、偏度和峰度）以及其他结果（包括高回声胰腺、高回声肝脏和糖尿病）的相关性。结果：年龄增加与弹性图参数（例如平均值（P = 0.004）、偏度（P = 0.007）和峰度（P = 0.03））之间存在显着相关性，并且这些差异变得显着40岁以后，胰腺高回声的患病率随着年龄的增长而增加（P<0.001），胰腺高回声的平均值较低（P=0.004），体重指数较高（BMI，P=0.008）。与糖尿病、肝脏高回声或弹性成像参数没有显着相关性。结论：应变弹性成像显示胰腺随着年龄的增长而发生弹性成像变化，包括40岁后均值减小、偏度和峰度增加。胰腺高回声发生率增加，且胰腺高回声与均值显着负相关。 (C) 2016 Elsevier B.V. 保留所有权利。
Background: Ultrasound strain elastography is one of the useful methods for evaluating pancreatic lesions. During aging, several pancreatic parenchymal changes occur that may interfere with the interpretation of the ultrasound images. We studied age-related changes in pancreatic elasticity using transabdominal ultrasound strain elastography in subjects without known pancreatic disease.Methods: This study was conducted at Nagoya University Hospital, which is an academic medical center, and included 102 subjects (66 women and 39 men) aged 20-85 years (mean 58.6 +/- 17.5) who underwent transabdominal ultrasonography for screening and follow-up for non-pancreatic diseases. Strain elastography of the pancreas was performed, and the results were subjected to quantitative strain histogram analysis. The correlations of age with four elastographic parameters (Mean, Standard deviation, Skewness, and Kurtosis) and other findings, including hyperechoic pancreas, hyperechoic liver, and diabetes, were evaluated.Results: There was a significant correlation between increasing age and elastographic parameters such as the Mean (P = 0.004), Skewness (P = 0.007), and Kurtosis (P = 0.03), and these differences became significant after the age of 40. The prevalence of hyperechoic pancreas increased with age (P < 0.001), and the Means were lower in those with hyperechoic pancreas (P = 0.004) and a higher body mass index (BMI, P = 0.008). No significant correlations with diabetes, hyperechoic liver, or elastographic parameters were demonstrated.Conclusion: Strain elastography demonstrated elastographic changes in the pancreas with aging that included a decreasing Mean and increasing Skewness and Kurtosis after the age of 40. The prevalence of pancreatic hyperechogenicity increased, and the pancreatic hyperechogenicity was significantly negatively correlated with the Mean. (C) 2016 Elsevier B.V. All rights reserved.