MOF-74/polystyrene-derived Ni-doped hierarchical porous carbon for structure-oriented extraction of polycyclic aromatic hydrocarbons and their metabolites from human biofluids.
MOF-74/polystyrene-derived Ni-doped hierarchical porous carbon for structure-oriented extraction of polycyclic aromatic hydrocarbons and their metabolites from human biofluids.
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DOI：
10.1016/j.jhazmat.2021.127465
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发表时间：
2021-10
影响因子：
13.6
通讯作者：
Yueru Shi;Junlong Huang;Luyi Chen;Shaohan Wang;Jianqiao Xu;Fang Zhu;Shufen Cui;Juan Zheng;
中科院分区：
文献类型：
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作者：
Yueru Shi;Junlong Huang;Luyi Chen;Shaohan Wang;Jianqiao Xu;Fang Zhu;Shufen Cui;Juan Zheng;
多环芳烃（Polycyclicaromatic hydrocarbons，PAHs）是肺癌的主要致癌物质，严重危害着人类的健康。多环芳烃及其代谢产物（羟基化多环芳烃，OH-PAHs）的分析对于生物监测和暴露评估具有重要意义。然而，由于多环芳烃和羟基多环芳烃的物理化学性质差异和基质干扰，实现两者的高效萃取仍然是一个挑战。本文中，通过碳化聚苯乙烯（PS）渗透的金属-有机框架（M0 F-74（Ni））来合成镍掺杂的分级多孔碳（Ni/HPC）。所得Ni/HPC具有分级孔和均匀分布的Ni原子，提供有效的扩散途径和吸附位点。自制的Ni/HPC涂层固相微萃取（SPME）光纤在各种干扰条件下对多环芳烃及其代谢物表现出上级富集能力，验证了其在真实的样品分析中的实用性。该方法为合成碳基吸附剂提供了一种新的策略，实现了对PAHs和OH-PAHs的抗基质富集，简化了环境分析和临床诊断的相关样品制备过程。
Polycyclic aromatic hydrocarbons (PAHs), as a major source that significantly increase the risk of developing lung cancer, severely jeopardize public health in modern society. The analysis of PAHs and their metabolites (hydroxylated PAHs, OH-PAHs) is important for biomonitoring and exposure assessment. However, due to the difference in their physico-chemical properties and matrix interference, realizing high-performance extraction of both PAHs and OH-PAHs is still a challenge. Herein, a nickel-doped hierarchical porous carbon (Ni/HPC) is synthesized by carbonizing the polystyrene (PS) infiltrated metal-organic frameworks (MOF-74(Ni)). The obtained Ni/HPC exhibits hierarchical pores and evenly distributed Ni atoms, providing efficient diffusion pathways and adsorption sites. The custom Ni/HPC-coated solid-phase microextraction (SPME) fiber shows superior enrichment capabilities for PAHs and their metabolites under various interfering conditions, verifying its practicability in real sample analysis. The proposed method provides a new strategy to synthesize carbon-based adsorbents that achieves matrix-resistant enrichment of PAHs and OH-PAHs, which simplifies the related sample preparation process for environmental analysis and clinical diagnosis.