Circulating autoantibodies against neuroblastoma suppressor of tumorigenicity 1 (NBL1): A potential biomarker for coronary artery disease in patients with obstructive sleep apnea.
Circulating autoantibodies against neuroblastoma suppressor of tumorigenicity 1 (NBL1): A potential biomarker for coronary artery disease in patients with obstructive sleep apnea.
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DOI：
10.1371/journal.pone.0195015
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Tatsumi K
中科院分区：
文献类型：
--
作者：
Matsumura T;Terada J;Kinoshita T;Sakurai Y;Yahaba M;Tsushima K;Sakao S;Nagashima K;Ozaki T;Kobayashi Y;Hiwasa T;Tatsumi K
尽管严重阻塞性睡眠呼吸暂停（OSA）是包括冠状动脉疾病（CAD）在内的动脉粥样硬化相关疾病的重要危险因素，但在OSA患者中没有可靠的CAD风险生物标志物。本研究旨在验证我们的假设，即循环中针对神经母细胞瘤致瘤性抑制因子1（NBL 1-Abs）的自身抗体与OSA患者中CAD的患病率相关。连续入选82例经多导睡眠图诊断为OSA的成人，96例诊断为急性冠状动脉综合征（ACS）的患者和64例健康志愿者（HV）。从诊断性多导睡眠图的OSA患者和疾病发作的ACS患者中收集血清样品。采用放大发光近均相法测定血清NBL 1-Ab水平，并评价其与动脉粥样硬化相关临床变量的相关性。与HVs相比，OSA和ACS患者的NBL 1-Ab水平显着升高。亚组分析显示，重度OSA患者和有CAD病史的OSA患者的NBL 1-Ab水平显著升高。NBL 1-Ab水平与呼吸暂停低通气指数、年龄、平均SpO 2和觉醒指数之间存在弱相关性，而在有CAD病史的OSA患者中观察到的NBL 1-Ab水平显著高于无CAD病史的患者。使用逻辑回归模型的敏感性分析也表明，增加的NBL 1-Ab水平与OSA患者的既往CAD病史相关。NBL 1-Ab水平升高可能与OSA患者CAD的患病率相关，有待进一步证实。
Although severe obstructive sleep apnea (OSA) is an important risk factor for atherosclerosis-related diseases including coronary artery disease (CAD), there is no reliable biomarker of CAD risks in patients with OSA. This study aimed to test our hypothesis that circulating autoantibodies against neuroblastoma suppressor of tumorigenicity 1 (NBL1-Abs) are associated with the prevalence of CAD in patients with OSA. Eighty-two adults diagnosed with OSA by polysomnography, 96 patients with a diagnosis of acute coronary syndrome (ACS) and 64 healthy volunteers (HVs) were consecutively enrolled. Serum samples were collected from patients with OSA at diagnostic polysomnography and from patients with ACS at disease onset. Serum NBL1-Ab level was measured by amplified luminescence proximity homogeneous assay and its association with clinical variables related to atherosclerosis was evaluated. NBL1-Ab level was significantly elevated in patients with both OSA and ACS compared with HVs. Subgroup analyses showed that NBL1-Ab level was markedly higher in patients with severe OSA and OSA patients with a history of CAD. Weak associations were observed between NBL1-Ab level and apnea-hypopnea index, age, mean SpO2 and arousal index, whereas significantly higher NBL1-Ab levels were observed in OSA patients with a history of CAD than in those without a history of CAD. Sensitivity analysis using a logistic regression model also demonstrated that increased NBL1-Ab levels were associated with the previous history of CAD in patients with OSA. Elevated NBL1-Ab levels may be associated with the prevalence of CAD in patients with OSA, which needs to be confirmed further.
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影响因子：
--
作者：
Fesmire J;Wolfson-Reichlin M;Reichlin M
通讯作者：
Reichlin M
影响因子：
20.1
作者：
Sorescu, GP;Song, H;Jo, H
通讯作者：
Jo, H
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4.8
作者：
Garrigue-Antar, L;François, V;Kadler, KE
通讯作者：
Kadler, KE
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37.8
作者：
Csiszar, A;Smith, KE;Ungvari, Z
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Ungvari, Z
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39.3
作者：
Montecucco, Fabrizio;Vuilleumier, Nicolas;Roux-Lombard, Pascale
通讯作者：
Roux-Lombard, Pascale