[Occurrence of BOOP outside radiation field after radiation therapy for small cell lung cancer].
[Occurrence of BOOP outside radiation field after radiation therapy for small cell lung cancer].
复制标题
小细胞肺癌放射治疗后放射野外BOOP的发生[J].
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
S. Noma
中科院分区：
文献类型：
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作者：
T. Hamanishi;T. Morimatu;K. Oida;Yoshiaki Kori;Yoshio Taguchi;E. Tanaka;Tetsuro Inoue;Terufumi Kato;K. Maniwa;Y. Kobashi;S. Noma
我们报告一例小细胞肺癌放射治疗后在放射野外发生的闭塞性细支气管炎机化性肺炎（BOOP）病例。一名 74 岁女性因右肺门上区小细胞癌，接受了化疗和右肺门和纵隔总计 60 Gy 的放射治疗。放射治疗结束后3个月，放射口内发生放射性肺炎。她主诉咳嗽，并在放射治疗完成 7 个月后入院。胸部X光检查和计算机断层扫描显示接受放射治疗的对侧放射野外的周围肺泡混浊。支气管肺泡灌洗显示细胞总数增加，淋巴细胞百分比明显增加。经支气管肺活检显示与 BOOP 一致的组织学模式。皮质类固醇治疗使症状迅速改善，左肺放射学异常完全消失。尽管已有一些乳腺癌放射治疗后发生BOOP的病例报道，但文献中尚未出现肺癌放射治疗后发生BOOP的病例。
We report a case of bronchiolitis obliterans organizing pneumonia (BOOP) that occurred outside the radiation field after radiation therapy for small cell lung cancer. A 74-year-old woman received chemotherapy and a total of 60 Gy of radiation therapy to the right hilum and mediastinum for small cell carcinoma of the suprahilar area of the right lung. Radiation pneumonitis developed within the radiation port 3 months after the completion of radiation therapy. She complained of cough and was admitted 7 months after completion of the radiation therapy. Chest radiography and computed tomography demonstrated peripheral alveolar opacities outside the radiation field on the side contralateral to that receiving the radiation therapy. Bronchoalveolar lavage showed that the total cell count was increased, with a markedly increased percentage of lymphocytes. Transbronchial lung biopsy revealed a histologic pattern consistent with BOOP. Treatment with corticosteroids resulted in rapid improvement of the symptoms and complete resolution of the radiographic abnormalities of the left lung. Although some cases of BOOP following radiation therapy for breast cancer have been reported, none of BOOP after radiation therapy for lung cancer have appeared in the literature.