Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling.
Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling.
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Presenilin 1通过AKT信号传导调节稳态突触缩放。
DOI：
10.1038/nn.2893
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发表时间：
2011-08-14
影响因子：
25
通讯作者：
Sullivan JM
中科院分区：
文献类型：
--
作者：
Pratt KG;Zimmerman EC;Cook DG;Sullivan JM
体内和体外的神经元通过调节它们的突触强度来稳定放电频率，从而适应网络活动的长期变化。在这里，我们表明，兴奋性突触的动态平衡伸缩在缺乏早老素1(PS1−/−)或表达家族性阿尔茨海默病相关的PS1突变(PS1M146V)的小鼠海马神经元中受到损害。这些发现表明，突触稳态的缺陷可能是阿尔茨海默病患者大脑功能障碍的原因之一。
Neurons in vivo and in vitro adapt to long-lasting changes in network activity by adjusting their synaptic strengths to stabilize firing rates. Here we show that homeostatic scaling of excitatory synapses is impaired in mouse hippocampal neurons lacking presenilin 1 (PS1−/−) or expressing a familial Alzheimer’s disease-linked PS1 mutation (PS1M146V). These findings suggest that deficits in synaptic homeostasis may contribute to brain dysfunction in Alzheimer’s disease.