Frontal and motor cortex oxygenation during maximal exercise in normoxia and hypoxia
Frontal and motor cortex oxygenation during maximal exercise in normoxia and hypoxia
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DOI：
10.1152/japplphysiol.91475.2008
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发表时间：
2009-04-01
影响因子：
3.3
通讯作者：
Roach, Robert C.
中科院分区：
文献类型：
--
作者：
Subudhi, Andrew W.;Miramon, Brittany R.;Roach, Robert C.
Subudhi AW、Miramon BR、Granger ME、Roach RC。常氧和缺氧条件下最大运动期间额叶和运动皮层的氧合。 J Appl Physiol 106: 1153-1158, 2009。首次发表于 2009 年 1 月 15 日； doi:10.1152/japplphyol.91475.2008.-接近最大运动量时前额叶氧合的减少可能会损害影响停止运动决定的执行功能，从而限制运动表现；然而，脱氧是否也发生在更直接影响中枢电机驱动的运动区域尚不清楚。使用多通道近红外光谱来比较力竭运动期间前额叶、前运动和运动皮质的变化。 23 名受试者在环境室中的急性缺氧 [79 Torr 激发 PO2 (PIO2)] 和常氧 (117 Torr PIO2) 期间进行了两次连续增量循环测试（25 W/min 斜坡）。测试顺序是平衡的，受试者对室内压力不知情。在含氧量正常的情况下，双侧前额叶氧合在低强度和中等强度运动期间保持不变，但在力竭前下降 9.0 +/- 10.7%（平均值 +/- SD，P < 0.05）（最大功率 = 305 +/- 52 W）。前额叶、运动前和运动区域的脱氧模式和程度相似（R-2 > 0.94）。在缺氧状态下，静息时前额叶氧合减少 11.1 +/- 14.3% (P < 0.01)，力竭时又下降 26.5 +/- 19.5% (P < 0.01)（最大功率 = 256 +/- 38 W，P < 0.01）。区域之间的相关性很高（R-2 > 0.61），但前额叶的脱氧程度高于运动前区和运动区（P < 0.05）。高强度运动期间前额叶、运动前皮层和运动皮层脱氧可能有助于做出停止运动的综合决定。缺氧时皮质脱氧速度加快可能会加速这种效应。
Subudhi AW, Miramon BR, Granger ME, Roach RC. Frontal and motor cortex oxygenation during maximal exercise in normoxia and hypoxia. J Appl Physiol 106: 1153-1158, 2009. First published January 15, 2009; doi:10.1152/japplphysiol.91475.2008.-Reductions in prefrontal oxygenation near maximal exertion may limit exercise performance by impairing executive functions that influence the decision to stop exercising; however, whether deoxygenation also occurs in motor regions that more directly affect central motor drive is unknown. Multichannel near-infrared spectroscopy was used to compare changes in prefrontal, premotor, and motor cortices during exhaustive exercise. Twenty-three subjects performed two sequential, incremental cycle tests (25 W/min ramp) during acute hypoxia [79 Torr inspired PO2 (PIO2)] and normoxia (117 Torr PIO2) in an environmental chamber. Test order was balanced, and subjects were blinded to chamber pressure. In normoxia, bilateral prefrontal oxygenation was maintained during low-and moderate-intensity exercise but dropped 9.0 +/- 10.7% (mean +/- SD, P < 0.05) before exhaustion (maximal power = 305 +/- 52 W). The pattern and magnitude of deoxygenation were similar in prefrontal, premotor, and motor regions (R-2 > 0.94). In hypoxia, prefrontal oxygenation was reduced 11.1 +/- 14.3% at rest (P < 0.01) and fell another 26.5 +/- 19.5% (P < 0.01) at exhaustion (maximal power = 256 +/- 38 W, P < 0.01). Correlations between regions were high (R-2 > 0.61), but deoxygenation was greater in prefrontal than premotor and motor regions (P < 0.05). Prefrontal, premotor, and motor cortex deoxygenation during high-intensity exercise may contribute to an integrative decision to stop exercise. The accelerated rate of cortical deoxygenation in hypoxia may hasten this effect.