When do myopia genes have their effect? Comparison of genetic risks between children and adults
When do myopia genes have their effect? Comparison of genetic risks between children and adults
复制标题
近视基因什么时候发挥作用？
DOI：
10.1002/gepi.21999
复制
发表时间：
2016-12-01
影响因子：
2.1
通讯作者：
Klaver, Caroline C. W.
中科院分区：
文献类型：
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作者：
Tideman, J. Willem L.;Fan, Qiao;Klaver, Caroline C. W.
先前的研究已经确定了许多屈光不正和近视的遗传位点。我们的目的是调查这些基因座对儿童、青少年和成人眼生物测量的影响。研究人群由国际CREAM联盟确定的三个年龄组组成：5，490名25岁的个体。所有参与者均接受标准眼科检查，包括测量眼轴长度（AL）和角膜半径（CR）。我们检测了全基因组关联研究（GWAS）中所有39个目前已知的屈光不正遗传位点的主要SNP，以及联合遗传风险评分（GRS）。在三个年龄组中比较SNP基因型或GRS与AL/CR之间关联的β系数，调整年龄、性别和主成分。分析是Bonferroni校正的。年龄组
Previous studies have identified many genetic loci for refractive error and myopia. We aimed to investigate the effect of these loci on ocular biometry as a function of age in children, adolescents, and adults. The study population consisted of three age groups identified from the international CREAM consortium: 5,490 individuals aged 25 years. All participants had undergone standard ophthalmic examination including measurements of axial length (AL) and corneal radius (CR). We examined the lead SNP at all 39 currently known genetic loci for refractive error identified from genome-wide association studies (GWAS), as well as a combined genetic risk score (GRS). The beta coefficient for association between SNP genotype or GRS versus AL/CR was compared across the three age groups, adjusting for age, sex, and principal components. Analyses were Bonferroni-corrected. In the age group