DYE-SENSITIZED PHOTOOXIDATION OF ESCHERICHIA COLI RIBOSOME
DYE-SENSITIZED PHOTOOXIDATION OF ESCHERICHIA COLI RIBOSOME
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DOI：
10.1126/science.164.3879.583
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发表时间：
1969-01-01
期刊：
影响因子：
56.9
通讯作者：
ROGERS, SJ
中科院分区：
文献类型：
--
作者：
GARVIN, RT;JULIAN, GR;ROGERS, SJ
在选定的光敏染料存在下，通过氧化对大肠杆菌核糖体进行化学修饰，导致其氨基酸结合能力迅速丧失。通过比较敏化核糖核酸中鸟嘌呤或蛋白质中氨基酸残基的光氧化的染料的效率，推断一种或多种功能性核糖体蛋白的失活。
Chemical modification of ribosomes fromEscherichia coliby oxidation in the presence of selected photosensitizing dyes causes a rapid loss of their amino acid-incorporating ability. By comparing the efficiency of dyes that sensitize the photooxidation of either guanine in ribonucleic acid or amino acid residues in proteins, inactivation of one or more functional ribosomal proteins is inferred.