TRUNCATED GLUCAGONLIKE PEPTIDE-I, AN INSULIN-RELEASING HORMONE FROM THE DISTAL GUT
TRUNCATED GLUCAGONLIKE PEPTIDE-I, AN INSULIN-RELEASING HORMONE FROM THE DISTAL GUT
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DOI：
10.1016/0014-5793(87)81430-8
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发表时间：
1987-01-26
期刊：
影响因子：
3.5
通讯作者：
SCHWARTZ, TW
中科院分区：
文献类型：
--
作者：
HOLST, JJ;ORSKOV, C;SCHWARTZ, TW
通过疏水凝胶渗透和高压液相色谱法，我们从猪肠粘膜中分离出一种肽，其对应于胰高血糖素原78-107，如通过色谱法和其N末端序列测定所示。天然和合成的胰高血糖素原78-107剂量依赖性地和有效地增加了来自分离的灌注猪胰腺的胰岛素分泌。也由小肠分泌的胰高血糖素原78-107可参与胰岛素分泌的激素控制。
By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78–107 as suggested by chromatography and determination of its N‐terminal sequence. Natural and synthetic proglucagon 78–107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78–107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.