Batch versus Flow Photochemistry: A Revealing Comparison of Yield and Productivity
Batch versus Flow Photochemistry: A Revealing Comparison of Yield and Productivity
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DOI：
10.1002/chem.201404347
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发表时间：
2014-11-10
影响因子：
4.3
通讯作者：
Booker-Milburn, Kevin I.
中科院分区：
文献类型：
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作者：
Elliott, Luke D.;Knowles, Jonathan P.;Booker-Milburn, Kevin I.
近年来，许多研究小组报道了流动光化学的应用及其明显优于分批法的优点。为了严格确定流是否确实具有优于批处理的优势，在两种反应器模式中优化了广泛的合成光化学转化，并比较了它们的产率和生产率。令人惊讶的是，产率在所有比较情况下基本相同。更有启发性的是观察到，当关键反应参数匹配时，流动反应器的生产率与其间歇反应器的生产率变化很小。单层氟化乙烯丙烯（FEP）的反应器的平均生产率比间歇式反应器低20%，而三层反应器的生产率高出20%。最后，流动化学的效用被证明在开环反应的一个潜在的爆炸性[1.1.1]螺桨烷与丁烷-2，3-二酮的放大。
The use of flow photochemistry and its apparent superiority over batch has been reported by a number of groups in recent years. To rigorously determine whether flow does indeed have an advantage over batch, a broad range of synthetic photochemical transformations were optimized in both reactor modes and their yields and productivities compared. Surprisingly, yields were essentially identical in all comparative cases. Even more revealing was the observation that the productivity of flow reactors varied very little to that of their batch counterparts when the key reaction parameters were matched. Those with a single layer of fluorinated ethylene propylene (FEP) had an average productivity 20% lower than that of batch, whereas three-layer reactors were 20% more productive. Finally, the utility of flow chemistry was demonstrated in the scale-up of the ring-opening reaction of a potentially explosive [1.1.1] propellane with butane-2,3-dione.