The role of nuclear hormone receptors in cutaneous wound repair.
The role of nuclear hormone receptors in cutaneous wound repair.
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DOI：
10.1002/cbf.3086
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发表时间：
2015-01
影响因子：
3.6
通讯作者：
Lisse, Thomas S.
中科院分区：
文献类型：
--
作者：
Rieger, Sandra;Zhao, Hengguang;Martin, Paige;Abe, Koichiro;Lisse, Thomas S.
关键词：
皮肤伤口修复过程涉及平衡一系列动态事件，包括炎症、氧化应激、细胞迁移、增殖、存活和分化。一系列复杂的分泌的营养因子、细胞因子、表面和细胞内蛋白以时空方式表达以恢复创伤后的皮肤完整性。组织修复过程的启动、维持或终止受损可导致愈合紊乱、坏死、纤维化甚至癌症。皮肤环境中的核激素受体（NHR）调节组织修复过程，例如纤维增生和血管生成。功能性NHR及其配体的缺陷与慢性不愈合伤口和皮肤内分泌疾病的临床表型相关。NHR和皮肤小生境细胞（例如表皮角质形成细胞和真皮成纤维细胞）之间的功能关系对于成功的伤口闭合和永久修复是关键的。这篇综述的目的是描述皮肤的影响和各种核受体对功能组织修复损伤后的串扰。版权所有© 2014约翰威利父子有限公司.
The cutaneous wound repair process involves balancing a dynamic series of events ranging from inflammation, oxidative stress, cell migration, proliferation, survival and differentiation. A complex series of secreted trophic factors, cytokines, surface and intracellular proteins are expressed in a temporospatial manner to restore skin integrity after wounding. Impaired initiation, maintenance or termination of the tissue repair processes can lead to perturbed healing, necrosis, fibrosis or even cancer. Nuclear hormone receptors (NHRs) in the cutaneous environment regulate tissue repair processes such as fibroplasia and angiogenesis. Defects in functional NHRs and their ligands are associated with the clinical phenotypes of chronic non-healing wounds and skin endocrine disorders. The functional relationship between NHRs and skin niche cells such as epidermal keratinocytes and dermal fibroblasts is pivotal for successful wound closure and permanent repair. The aim of this review is to delineate the cutaneous effects and cross-talk of various nuclear receptors upon injury towards functional tissue restoration. Copyright © 2014 John Wiley & Sons, Ltd.
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DOI：
10.1084/jem.20100500
发表时间：
2010-08-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Campbell L;Emmerson E;Davies F;Gilliver SC;Krust A;Chambon P;Ashcroft GS;Hardman MJ
通讯作者：
Hardman MJ
影响因子：
6.5
作者：
Ashcroft, GS;Horan, MA;Ferguson, MWJ
通讯作者：
Ferguson, MWJ
DOI：
10.1016/0022-4731(86)90296-7
发表时间：
1986-07-01
影响因子：
4.1
作者：
CHABAB, A;SULTAN, C;DESCOMPS, B
通讯作者：
DESCOMPS, B
影响因子：
15.9
作者：
Ashcroft, GS;Mills, SJ
通讯作者：
Mills, SJ
影响因子：
--
作者：
Beer, H D;Fassler, R;Werner, S
通讯作者：
Werner, S