Smoking reduction and cessation reduce chronic cough in a general population: the Inter99 study
Smoking reduction and cessation reduce chronic cough in a general population: the Inter99 study
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DOI：
10.1111/j.1752-699x.2007.00029.x
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发表时间：
2008-01-01
影响因子：
1.7
通讯作者：
Jorgensen, Torben
中科院分区：
文献类型：
--
作者：
Pisinger, Charlotta;Godtfredsen, Nina S.;Jorgensen, Torben
背景：慢性咳嗽可能是慢性阻塞性疾病的首发症状。一些研究表明，减少日常烟草消费对肺部症状的影响很小，而且大多数研究都是精选的。目的：本研究的目的是检验减少吸烟(SR；=每日烟草消费量的50%)或戒烟(SC)是否对慢性咳嗽和痰有影响。方法：共有2408名每日吸烟者参加了一项丹麦基于人群的干预研究，Inter99。在分析中，我们包括了在基线时有自我报告的慢性咳嗽或痰的吸烟者，他们也参加了为期1年的随访。结果：近34%的吸烟者在基线时有慢性咳嗽，24.5%有慢性痰。基线时有咳嗽的患者有37人，基线时有痰的患者有24人，在1年的随访期内获得了显著的缓解率。SC的相应数字分别为63和39。在调整后的分析中，与吸烟习惯不变相比，戒烟或减少吸烟分别与较少报告咳嗽相关[优势比(OR)：14.2；95%可信区间(CI)：5.9-34，4]和(OR：3.7；95%CI：1.7-8.0)。与持续吸烟者相比，戒烟者在1年的随访期内不报告痰的可能性也显著增加(OR：7.1；95%CI：2.8-18.0)，而SR与终止痰无关(OR：2.5；95%CI：0.9-6.4)。结论：SC如预期的那样显著改善了自我报告的慢性咳嗽和痰。少数吸烟者获得了显著的缓解率，但对慢性咳嗽有显著的积极作用。
Background: Chronic cough can be the first sign of chronic obstructive disease. A few, and mostly selected, studies exploring the effect of reduced daily tobacco consumption have shown a small effect on pulmonary symptoms. Aim: The aim of this study was to examine if smoking reduction (SR) (>= 50% of daily tobacco consumption) or smoking cessation (SC) had an effect on chronic cough and phlegm.Methods: A total of 2408 daily smokers were included in a Danish population-based intervention study, Inter99. In the analyses, we included smokers with self-reported chronic cough or phlegm at baseline who also attended the 1-year follow-up. We investigated if SR or SC had improved the self-reported pulmonary symptoms, using logistic regression analyses.Results: Almost 34% of the smokers had chronic cough at baseline and 24.5% had chronic phlegm. Thirty-seven persons with cough at baseline and 24 with phlegm at baseline achieved substantial SR at 1-year follow-up. The corresponding numbers for SC were 63 and 39, respectively. In adjusted analyses, quitting or reducing smoking was associated with less reporting of cough [odds ratio (OR): 14.2; 95% confidence interval (CI): 5.9-34,4] and (OR: 3.7; 95% CI: 1.7-8.0), respectively, compared with unchanged smoking habits. It was also significantly more likely not to report phlegm at 1-year follow-up for those who had quit (OR: 7.1; 95% CI: 2.8-18.0), whereas SR was not significantly associated with termination of phlegm (OR: 2.5; 95% CI: 0.9-6.4) when compared with continuous smoking.Conclusion: SC significantly improved self-reported chronic cough and phlegm as expected. Substantial SR was achieved by few smokers but had a significantly positive effect on chronic cough.