Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker.
Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker.
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DOI：
10.1016/j.bmcl.2008.12.052
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发表时间：
2009-02
影响因子：
2.7
通讯作者：
Taiwei Chu;Zejun Li;Xiangyun Wang
中科院分区：
文献类型：
--
作者：
Taiwei Chu;Zejun Li;Xiangyun Wang
N-[4-(Benzothiazol-2-yl)phenyl]-11-(2-nitroimidazole-1-yl)undecanamide (2NUBTA) was synthesized and radiolabeled with iodine-131. In vitro evaluation of the [131I]2NUBTA using murine sarcoma S180 cells showed increase in radioactivity in hypoxic cells up to 4h, while it was not in aerobic cells. Its potential as a cerebral ischemia marker was evaluated using gerbil stroke models that had been subjected to right common carotid artery ligation to produce cerebral ischemia. The uptake in the right cerebral hemisphere decreased slowly than that of the left and the right/left hemisphere uptake ratios increased with time going on. It indicated that [131I]2NUBTA might be a possible cerebral ischemia marker.
