Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups
Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups
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不同种族群体的腹腔内和肝脏脂肪沉积倾向存在差异。
DOI：
10.1053/j.gastro.2018.11.021
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发表时间：
2019-03-01
期刊：
影响因子：
29.4
通讯作者：
Le Marchand, Loic
中科院分区：
文献类型：
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作者：
Lim, Unhee;Monroe, Kristine R.;Le Marchand, Loic
背景与目的：我们比较了来自5个不同种族的个体腹部脂肪储存，以确定脂肪储存是否与代谢综合征和其他肥胖相关疾病的差异有关。方法：我们收集了1794名多种族队列研究参与者的数据（60-77岁，非洲人、欧洲[白人]、日本人、拉丁美洲人或夏威夷原住民血统），体重指数为17.1-46.2 kg/m(2)。从2013年5月到2016年4月，参与者前往研究诊所进行身体测量、访谈和采血。参与者通过双能x线吸收仪和腹部磁共振成像进行评估。在不同种族人群中，我们比较了躯干、腹腔和肝脏的脂肪含量，并根据总脂肪量进行了调整；我们评估了成人体重变化与腹部肥胖的关系；我们检查了由腹部肥胖引起的代谢综合征的患病率。结果：躯干、内脏和肝脏脂肪的相对含量因种族而异，日裔美国人最高，非裔美国人最低，其他群体居中。与非裔美国人相比，日裔美国男性和女性的平均内脏脂肪面积分别大45%和73%，日裔美国男性和女性的平均肝脏脂肪面积分别大61%和122%。自参与者21岁起，与体重增加相关的内脏和肝脏肥胖在不同种族群体中也有类似的变化模式。在中介分析中，与白人、非裔美国人、日裔美国人和夏威夷土著妇女相比，内脏脂肪和肝脏脂肪共同占代谢综合征患病率差异的统计学显著部分，独立于总脂肪量。结论：在对多种族队列研究参与者的数据分析中，我们发现不同种族群体在腹部脂肪储存倾向方面存在广泛差异。临床医生在预防和早期发现代谢紊乱时应考虑这一观察结果。
BACKGROUND & AIMS: We compared fat storage in the abdominal region among individuals from 5 different ethnic-racial groups to determine whether fat storage is associated with disparities observed in metabolic syndrome and other obesity-associated diseases. METHODS: We collected data from 1794 participants in the Multiethnic Cohort Study (60-77 years old; of African, European [white], Japanese, Latino, or Native Hawaiian ancestry) with body mass index values of 17.1-46.2 kg/m(2). From May 2013 through April 2016, participants visited the study clinic to undergo body measurements, an interview, and a blood collection. Participants were evaluated by dual-energy x-ray absorptiometry and abdominal magnetic resonance imaging. Among ethnic groups, we compared adiposity of the trunk, intra-abdominal visceral cavity, and liver, adjusting for total fat mass; we evaluated the association of adult weight change with abdominal adiposity; and we examined the prevalence of metabolic syndrome mediated by abdominal adiposity. RESULTS: Relative amounts of trunk, visceral, and liver fat varied significantly with ethnicity-they were highest in Japanese Americans, lowest in African Americans, and intermediate in the other groups. Compared with African Americans, the mean visceral fat area was 45% and 73% greater in Japanese American men and women, respectively, and the mean measurements of liver fat were 61% and 122% greater in Japanese American men and women. The visceral and hepatic adiposity associated with weight gain since participants were 21 years old varied in a similar pattern among ethnic-racial groups. In the mediation analysis, visceral and liver fat jointly accounted for a statistically significant fraction of the difference in metabolic syndrome prevalence, compared with white persons, for African Americans, Japanese Americans, and Native Hawaiian women, independently of total fat mass. CONCLUSIONS: In an analysis of data from the participants in the Multiethnic Cohort Study, we found extensive differences among ethnic-racial groups in the propensity to store fat intra-abdominally. This observation should be considered by clinicians in the prevention and early detection of metabolic disorders.