Apoptosis and necroptosis in the liver: a matter of life and death.
Apoptosis and necroptosis in the liver: a matter of life and death.
复制标题
肝脏中的凋亡和坏死性：生死攸关的问题。
DOI：
10.1038/s41575-018-0065-y
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Luedde T
中科院分区：
文献类型：
--
作者：
Schwabe RF;Luedde T
细胞死亡代表了一种基本的生物学范式，几乎在每种肝病病症中都控制着结果和长期后遗症。急性肝功能衰竭的特征是实质细胞大量丢失，但通常随后恢复原状。相比之下，慢性肝病中的细胞死亡通常发生在较小程度上，但导致器官结构和功能的长期改变，有助于慢性肝细胞更新，免疫细胞的募集和肝星状细胞的活化，从而导致肝纤维化，肝硬化和癌症的发展。很明显，除了细胞凋亡，坏死性凋亡代表了肝脏中程序性细胞死亡（PCD）的一种高度相关的形式。特定形式的PCD的差异激活不仅可能影响肝脏疾病的结局，而且还为治疗干预提供了新的机会。在这里，我们将总结潜在的分子机制和开放的问题，疾病特异性激活和PCD形式的作用，它们对响应签名的贡献以及它们的检测。我们将重点关注细胞凋亡和坏死性凋亡在急性肝损伤，非酒精性脂肪性肝病（NAFLD），非酒精性脂肪性肝炎（NASH）和肝癌中的作用，以及可能转化为临床应用。
Cell death represents a basic biological paradigm that governs outcomes and long-term sequelae in almost every hepatic disease condition. Acute liver failure is characterized by massive loss of parenchymal cells but is usually followed by restitution ad integrum. By contrast, cell death in chronic liver diseases often occurs at lesser extents but leads to long-term alterations in organ architecture and function, contributing to chronic hepatocyte turnover, the recruitment of immune cells and activation of hepatic stellate cells, and thereby to the development of liver fibrosis, cirrhosis and cancer. It has become evident that besides apoptosis, necroptosis represents a highly relevant form of programmed cell death (PCD) in the liver. Differential activation of specific forms of PCD might not only affect outcomes in liver diseases, but also offer novel opportunities for therapeutic intervention. Here, we will summarize the underlying molecular mechanisms and open questions about disease-specific activation and roles of PCD forms, their contribution to response signatures as well as their detection. We will focus on the role of apoptosis and necroptosis in acute liver injury, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) and liver cancer, and possible translation into clinical applications.
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DOI：
10.1073/pnas.0812690106
发表时间：
2009-06-02
影响因子：
11.1
作者：
Cayrol, Corinne;Girard, Jean-Philippe
通讯作者：
Girard, Jean-Philippe
影响因子：
25.7
作者：
Savio LEB;de Andrade Mello P;Figliuolo VR;de Avelar Almeida TF;Santana PT;Oliveira SDS;Silva CLM;Feldbrügge L;Csizmadia E;Minshall RD;Longhi MS;Wu Y;Robson SC;Coutinho-Silva R
通讯作者：
Coutinho-Silva R
非酒精性脂肪肝疾病（NAFLD） - 对药物代谢酶和转运蛋白的发病机理，分类和影响。
影响因子：
5.9
作者：
Cobbina E;Akhlaghi F
通讯作者：
Akhlaghi F
影响因子：
9.8
作者：
Buzzetti, Elena;Pinzani, Massimo;Tsochatzis, Emmanuel A.
通讯作者：
Tsochatzis, Emmanuel A.
影响因子：
21.3
作者：
Friedmann Angeli JP;Schneider M;Proneth B;Tyurina YY;Tyurin VA;Hammond VJ;Herbach N;Aichler M;Walch A;Eggenhofer E;Basavarajappa D;Rådmark O;Kobayashi S;Seibt T;Beck H;Neff F;Esposito I;Wanke R;Förster H;Yefremova O;Heinrichmeyer M;Bornkamm GW;Geissler EK;Thomas SB;Stockwell BR;O'Donnell VB;Kagan VE;Schick JA;Conrad M
通讯作者：
Conrad M