A 21-plex DIP panel’s application in multinational Chinese population
A 21-plex DIP panel’s application in multinational Chinese population
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21重DIP面板在跨国华人人群中的应用
DOI：
10.1016/j.fsigss.2015.09.212
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发表时间：
2015
影响因子：
--
通讯作者：
Lin Zhang
中科院分区：
文献类型：
--
作者：
Youjing Jiang;Li Wang;Zhilong Li;Jing Zhu;Duo Peng;Qin Su;Jiong Mao;Hui Wang;Weibo Liang;Lin Zhang
插入/缺失多态性（DIP）结合了单核苷酸多态性（SNPs）和短串联重复序列（STR）的优点，在法医学个案工作中具有重要的应用价值。由丹尼尔等人开发的高灵敏度21 AIM（祖先信息标记）-DIP组足以区分三个主要的全球人群。然而，丹尼尔的研究并没有包括中国人口。本研究按照丹尼尔的方法，对中国西部汉族、维吾尔族和藏族三个群体的DNA进行了提取和分析。比较了中国三个人群的地理祖先差异。结果表明，中国汉族、维吾尔族和藏族人群之间没有显著差异。总之，该21重DIP检测板无法区分3个中国人群。为了表征中国的三个群体，需要更多的AIM-DIP。
DIPs (insertion/deletion polymorphisms) combining the advantages of both SNPs (single nucleotide polymorphisms) and STRs (short tandem repeats) show a great value in forensic case works. A high sensitive 21 AIM (ancestry informative markers)-DIPs panel developed by Daniel et al. is sufficient to distinguish between three major global population groups. However, Chinese population was not included in Daniel’s research. In this study, DNA samples from three Chinese population groups living in west of China (Han (n= 60), Uighur (n= 60) and Tibetan (n= 60)) were extracted and analyzed following Daniel’s procedure. The difference in biogeographic ancestry between the three Chinese population groups was compared. The consequence shows no significant difference between Chinese Han, Uighur and Tibetan populations. In summary, this 21-plex DIP panel is unable to distinguish the three Chinese populations. To characterize three groups in China, more AIM-DIPs are needed.