CENTRAL DISTRIBUTION OF SUBDIAPHRAGMATIC VAGAL BRANCHES IN THE RAT
CENTRAL DISTRIBUTION OF SUBDIAPHRAGMATIC VAGAL BRANCHES IN THE RAT
复制标题
DOI：
10.1002/cne.902730206
复制
发表时间：
1988-07-08
影响因子：
2.5
通讯作者：
SMITH, GP
中科院分区：
文献类型：
--
作者：
NORGREN, R;SMITH, GP
在大鼠中，延髓下迷走神经（SDX）具有精细的主要分支-右胃、左胃、腹腔、副腹腔和肝。虽然这些分支比它们命名的器官更多地受到支配，但有些分支介导特定的行为功能。除了SDX主干外，还将这些分支的中央残端在麻醉大鼠的辣根过氧化物酶（HRP）中孵育6小时。处理每种制备物的迷走神经节、脑桥、延髓和上颈脊髓后，检查切片的逆行和顺行运输HRP反应产物。当只有一个神经已孵育，逆行标记的中子主要局限于同侧神经节，髓质，和脊髓。在脑内，少数标记神经元出现在疑核（NA）和网状结构尾侧的NA，但绝大多数出现在迷走神经背侧运动核（DMX）。NA内标记神经元的轴突主要分布在胃支，NA尾侧的标记神经元的轴突可能分布在腹腔分支。标记的DMX细胞也多分布于胃支。然而，右侧DMX侧端的轴突位于腹腔分支;左侧DMX端的轴突位于副腹腔。SDX干孵育后，顺行HRP反应产物出现在孤束尾内侧核（NST）的吻侧和最后区（AP）下方。与逆行标记不同，顺行反应产物是双侧的，但对侧总是较弱。在SDX分布中，来自胃分支的传入轴突表现出一种终止模式;来自腹腔、副腹腔和肝分支的传入轴突表现出另一种终止模式。胃分支分布始于SDX终止区的背外侧，并在AP下方继续向尾侧延伸。在AP附近，胃分支终末不密集，整个分布在奥贝水平消失。腹腔和副腹腔分布开始于SDX终止区内的背内侧，并在紧挨着AP的薄带中向尾侧加强。尾侧标记与AP的尾侧半部分相关，但分布在奥贝的尾部迅速变薄。肝脏分布与腹腔分支相似，但从未达到相似的密度。生理和行为数据与解剖图片相关，传出功能似乎比传入功能更密集地定位。
In the rat, the subdiaphragmatic vagus nerves (SDX) have fine major branches-the right gastric, the left gastric, the coeliac, the accessory coeliac, and the hepatic. Although these branches innervate more than the organs after which they are named, some mediate specific behavioral functions. In addition to the SDX trunk, the central stump of each of these branches was incubated in horseradish peroxidase (HRP) for 6 hours in anesthetized rats. After processing the vagal ganglia, pons, medulla, and upper cervical spinal cord of each preparation, the sections were examined for both retrogradely and anterogradely transported HRP reaction product. When only one nerve had been incubated, retrogradely labeled neutron were confined primarily to the ipsilateral ganglion, medulla, and spinal cord. Within the brain, a few labeled neurons occurred within the nucleus ambiguus (NA) and the reticular formation caudal to the NA, but the vast majority appeared in the dorsal motor nucleus of the vagus (DMX). The axons of most labeled neurons in the NA distributed in the gastric branches; those from cells caudal to the NA, probably distributed in the coeliac branch. Most labeled DMX cells also distributed with the gastric branches. Those on the lateral tip of the right DMX, however, had axons in the coeliac branch; those on the left DMX tip, in the accessory coeliac. After incubation of the SDX trunk, anterograde HRP reaction product occurred in the caudomedial nucleus of the solitary tract (NST) just rostral and subjacent to the area postrema (AP). Unlike the retrograde label, anterograde reaction product was bilateral, but always weaker contralaterally. Within the SDX distribution, the afferent axons from the gastric branches exhibited one pattern of termination; those from the coeliac, accessory coeliac, and hepatic branches, another. The gastric branch distributions began dorsolaterally in the SDX termination zone and continued caudally beneath the AP. Immediately subjacent to the AP, gastric branch terminals were never dense and the entire distribution faded at the level of the obex. The coeliac and accessory coeliac distributions began dorsomedially within the SDX termination zone and intensified caudally in a thin band immediately subjacent to the AP. The densest label was associated with the caudal half of the AP, but the distribution thinned rapidly caudal to the obex. The hepatic distribution was similar to that of the coeliac branches but never achieved similar density. Physiological and behavioral data correlate with the anatomical picture in that the efferent functions appear to be more densely localized than the afferent functions.