Mice Lacking MSK1 and MSK2 Show Reduced Skin Tumor Development in a Two-Stage Chemical Carcinogenesis Model
Mice Lacking MSK1 and MSK2 Show Reduced Skin Tumor Development in a Two-Stage Chemical Carcinogenesis Model
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DOI：
10.3109/07357907.2010.550594
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发表时间：
2011-03-01
影响因子：
2.4
通讯作者：
Johansen, Claus
中科院分区：
文献类型：
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作者：
Chang, Simon;Iversen, Lars;Johansen, Claus
有丝分裂原和应激激活蛋白激酶（MSK）1/2是参与炎症和细胞转化的两种激酶。目的：探讨MK 1/2在皮肤肿瘤发生中的作用。结果：与野生型小鼠相比，MSK 1/2基因敲除小鼠的皮肤肿瘤明显减少。与野生型小鼠相比，来自MSK 1/2敲除小鼠的TPA处理的皮肤中的髓过氧化物酶活性显著升高。此外，IL-1 β β的mRNA和蛋白水平以及TNF-α α的mRNA表达在MSK 1/2敲除小鼠中显著增加。结论：这些数据提供了在体内的证据，MSK 1/2信号转导代表了一个新的肿瘤促进轴在皮肤癌的发生。
Mitogen- and stress-activated protein kinase (MSK)1/2 are two kinases involved in inflammation as well as in cell transformation. Purpose: To examine the role of MSK1/2 in skin tumor development. Results: MSK1/2 knockout mice developed significantly fewer skin tumors compared with wild-type mice. The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice. Furthermore, the mRNA and protein levels of IL-1 beta beta as well as the mRNA expression of TNF-alpha alpha were significantly increased in MSK1/2 knockout mice. Conclusion: These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.