Radiotherapy for gastric lymphoma: a planning study of 3D conformal radiotherapy, the half-beam method, and intensity-modulated radiotherapy.
Radiotherapy for gastric lymphoma: a planning study of 3D conformal radiotherapy, the half-beam method, and intensity-modulated radiotherapy.
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DOI：
10.1093/jrr/rru052
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发表时间：
2014-11
影响因子：
2
通讯作者：
Itami J
中科院分区：
文献类型：
--
作者：
Inaba K;Okamoto H;Wakita A;Nakamura S;Kobayashi K;Harada K;Kitaguchi M;Sekii S;Takahashi K;Yoshio K;Murakami N;Morota M;Ito Y;Sumi M;Uno T;Itami J
在胃淋巴瘤的放射治疗过程中，当肝脏和肾脏与靶体积有相当大的重叠时，很难保护这些器官。本研究旨在比较四野三维适形放射治疗（3DCRT）、半野放射治疗（半射束法）和调强放射治疗（IMRT）三种放射治疗计划技术治疗计划靶区（PTV）与左肾重叠较大的原发性胃淋巴瘤。共纳入17例胃弥漫性大B细胞淋巴瘤（DLBCL）患者。在DLBCL中，免疫化疗（利妥昔单抗+ CHOP）后，对全胃和胃周围淋巴结进行40戈伊的放疗。比较3DCRT、半野法和调强放疗对肾脏、肝脏和PTV的剂量-体积直方图（DVH）参数和广义等效均匀剂量（gEUD）。在左肾和双肾，3DCRT的平均剂量和gEUD高于IMRT和半束法。3DCRT左肾平均剂量和gEUD分别为2117 cGy和2224 cGy，IMRT分别为1520 cGy和1637 cGy，半束法分别为1100 cGy和1357 cGy。双肾平均剂量和gEUD分别为1335 cGy和1559 cGy（3DCRT），1184 cGy和1311 cGy（IMRT），700 cGy和937 cGy（半束法）。剂量-体积直方图（DVH）显示3DCRT在<25戈伊剂量范围内照射的肝脏体积较大，而半束法在较高剂量范围内（>25戈伊）照射的肝脏体积较大。调强放射治疗和半射束方法具有减少肾脏和肝脏剂量的优点。
During radiotherapy for gastric lymphoma, it is difficult to protect the liver and kidneys in cases where there is considerable overlap between these organs and the target volume. This study was conducted to compare the three radiotherapy planning techniques of four-fields 3D conformal radiotherapy (3DCRT), half-field radiotherapy (the half-beam method) and intensity-modulated radiotherapy (IMRT) used to treat primary gastric lymphoma in which the planning target volume (PTV) had a large overlap with the left kidney. A total of 17 patients with gastric diffuse large B-cell lymphoma (DLBCL) were included. In DLBCL, immunochemotherapy (Rituximab + CHOP) was followed by radiotherapy of 40 Gy to the whole stomach and peri-gastric lymph nodes. 3DCRT, the half-field method, and IMRT were compared with respect to the dose–volume histogram (DVH) parameters and generalized equivalent uniform dose (gEUD) to the kidneys, liver and PTV. The mean dose and gEUD for 3DCRT was higher than for IMRT and the half-beam method in the left kidney and both kidneys. The mean dose and gEUD of the left kidney was 2117 cGy and 2224 cGy for 3DCRT, 1520 cGy and 1637 cGy for IMRT, and 1100 cGy and 1357 cGy for the half-beam method, respectively. The mean dose and gEUD of both kidneys was 1335 cGy and 1559 cGy for 3DCRT, 1184 cGy and 1311 cGy for IMRT, and 700 cGy and 937 cGy for the half-beam method, respectively. Dose–volume histograms (DVHs) of the liver revealed a larger volume was irradiated in the dose range <25 Gy with 3DCRT, while the half-beam method irradiated a larger volume of liver with the higher dose range (>25 Gy). IMRT and the half-beam method had the advantages of dose reduction for the kidneys and liver.
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影响因子：
3.4
作者：
Ringash, J;Khaksar, SJ;Brierley, J
通讯作者：
Brierley, J
DOI：
10.1016/j.ijrobp.2007.12.009
发表时间：
2008-08-01
影响因子：
7
作者：
Cheng, Jonathan C.;Schultheiss, Timothy E.;Wong, Jeffrey Y. C.
通讯作者：
Wong, Jeffrey Y. C.
DOI：
10.1016/j.ijrobp.2006.02.021
发表时间：
2006-07-15
影响因子：
7
作者：
Kal, Henk B.;Van Kempen-Harteveld, M. Loes
通讯作者：
Van Kempen-Harteveld, M. Loes
影响因子：
5.7
作者：
Esiashvili, Natia;Chiang, Kuang-Yueh;Paulino, Arnold C.
通讯作者：
Paulino, Arnold C.
DOI：
10.1016/j.ijrobp.2004.10.025
发表时间：
2005-07-01
影响因子：
7
作者：
Della Biancia, C;Hunt, M;Yahalom, J
通讯作者：
Yahalom, J