Connexin43: Emerging role in erectile function
Connexin43: Emerging role in erectile function
复制标题
DOI：
10.1016/j.biocel.2006.03.007
复制
发表时间：
2006-01-01
影响因子：
4
通讯作者：
Pointis, Georges
中科院分区：
文献类型：
--
作者：
Pointis, Georges
缝隙连接蛋白是在内分泌、神经、血管和肌肉等组织中大量表达的蛋白质，其主要功能是作为缝隙连接通道的一部分。缝隙连接与组织动态平衡以及细胞增殖和分化的控制有关。有趣的是，连接蛋白基因的突变已经在几种人类疾病(周围神经病、心血管和皮肤病、遗传性白内障和耳聋)中被报道，连接蛋白表达的改变与肿瘤的进展有关。今天，有几种研究主张缝隙连接在躯体平滑肌松弛和勃起反应中的关键作用。本文着重介绍了连接蛋白43在人类勃起功能的生理学和生理病理学中的作用及其可能的医学应用。(C)2006爱思唯尔有限公司。保留所有权利。
Connexins, that have their main function as part of gap junction channels, are proteins expressed in a large number of tissues such as endocrine, nervous, vascular, and muscular tissues. Gap junctions are implicated in tissue homeostasis and control of cell proliferation and differentiation. Interestingly, mutations of connexin genes have been reported in several human diseases (peripheral neuropathies, cardiovascular and dermatological diseases, hereditary cataract, and deafness) and altered expression of connexins have been associated with tumoral progression. Today, several lines of study argue for a. critical role of gap junctions in corporal smooth muscle relaxation and erectile response. The present review highlights the emerging role of connexin43, one of these membranous proteins, in the physiology and physiopathology of human erectile function and its possible medical application. (c) 2006 Elsevier Ltd. All rights reserved.