In vivo cartilage contact deformation in the healthy human tibiofemoral joint
In vivo cartilage contact deformation in the healthy human tibiofemoral joint
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DOI：
10.1093/rheumatology/ken345
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发表时间：
2008-11-01
期刊：
影响因子：
5.5
通讯作者：
Li, G.
中科院分区：
文献类型：
--
作者：
Bingham, J. T.;Papannagari, R.;Li, G.
目标。活体软骨接触变形是了解人类关节功能和退变的重要手段。本研究测量了人体胫股关节在负重屈曲过程中接触关节软骨的总变形。在受试者进行负重单腿弓步的同时，对11个健康的膝盖进行了磁共振(MR)扫描和双透视系统成像。根据MR图像构建胫骨、股骨及相关的关节软骨，并结合双面透视图像，测量关节软骨从完全伸展到120度屈曲时的活体接触变形。在负重屈曲从完全伸展到120度的过程中，两个椎室的最小峰值接触变形出现在屈曲30度(内侧24+/-6%，外侧17+/-7%)，最大峰值出现在屈曲120度(内侧30+/-13%，外侧30+/-10%)。平均内侧接触面积和峰值接触变形显著大于侧方间隔值(P<；0.05)。此外，接触区域的软骨厚度分别是胫骨和股骨软骨表面平均厚度的1.4倍和1.1倍(P<；0.05)。这些数据可能为研究不同膝关节损伤对关节接触生物力学的影响和软骨退变的病因提供基础知识。
Objectives. In vivo cartilage contact deformation is instrumental for understanding human joint function and degeneration. This study measured the total deformation of contacting articular cartilage in the human tibiofemoral joint during in vivo weight-bearing flexion.Methods. Eleven healthy knees were magnetic resonance (MR) scanned and imaged with a dual fluoroscopic system while the subject performed a weight-bearing single-leg lunge. The tibia, femur and associated articulating cartilage were constructed from the MR images and combined with the dual fluoroscopic images to determine in vivo cartilage contact deformation from full extension to 120 degrees of flexion.Results. In both compartments, minimum peak compartmental contact deformation occurred at 30 degrees of flexion (24 +/- 6% medial, 17 +/- 7% lateral) and maximum peak compartmental deformation occurred at 120 degrees of flexion (30 +/- 13% medial, 30 +/- 10% lateral) during the weight-bearing flexion from full extension to 120 degrees. Average medial contact areas and peak contact deformations were significantly greater than lateral compartment values (P < 0.05). In addition, cartilage thickness in regions of contact was on average 1.4- and 1.1-times thicker than the average thickness of the tibial and femoral cartilage surfaces, respectively (P < 0.05).Conclusions. These data may provide base- line knowledge for investigating the effects of various knee injuries on joint contact biomechanics and the aetiology of cartilage degeneration.