Multifunctional gap-enhanced Raman tags for preoperative and intraoperative cancer imaging
Multifunctional gap-enhanced Raman tags for preoperative and intraoperative cancer imaging
复制标题
用于术前和术中癌症成像的多功能间隙增强拉曼标签
DOI：
10.1016/j.actbio.2020.01.006
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发表时间：
2020-03-01
影响因子：
9.7
通讯作者：
Zhang, Huan
中科院分区：
文献类型：
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作者：
Shi, Bowen;Zhang, Benyan;Zhang, Huan
多模态显像剂在肿瘤诊断中具有重要的应用价值，因为它比单一的显像技术能为疾病的准确检测和治疗提供更多的替代性和可靠性信息。然而，大多数报道的常规显像剂尚未被发现成功地克服传统诊断的缺点，如灵敏度，空间分辨率，半衰期短和复杂性。因此，结合它们各自的形态特征开发多功能纳米复合材料对癌症的术前成像和术中诊断具有重要影响。在我们的研究中，介孔二氧化硅钆负载间隙增强的拉曼标签（Gd-GERT）专门用于术前和术中成像的设计和他们的成像能力和生物安全性进行了检查。它们对计算机X射线断层扫描（CT）成像表现出较强的衰减特性，对磁共振（MR）成像表现出较高的T-1弛豫能力，对表面增强拉曼光谱（Sers）信号表现出较好的分散性和稳定性，在一定时间内呈现出对小鼠肿瘤的CT/MR/Sers多模成像性能。此外，体内生物分布和长期毒性研究表明，Gd-GERT具有良好的生物相容性和生物安全性。因此，Gd-GERT作为一个多功能的纳米平台，准确的术前CT/MRI诊断和术中拉曼成像引导cancer.Statement的重要性声明最近的进展，分子成像技术提供了无数的机会，准备各种纳米材料，通过不同的成像模式的癌症的准确诊断和反应评估。然而，单一的生物成像模式仍然具有挑战性，以克服诸如灵敏度，空间分辨率，成像速度和复杂性的临床医生的问题。在这项工作中，我们设计了一种独特的多功能纳米探针与计算机X射线断层扫描/磁共振/表面增强拉曼光谱（CT/MR/Sers）三模式成像能力。多功能纳米标签提供术前非侵入性CT/MR成像以识别肿瘤以及术中实时Sers成像以指导完全切除肿瘤的能力。这些多功能纳米探针对提高肿瘤的诊断和治疗水平具有重要的临床意义。(C)2020 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Multi-modality imaging agents are desirable for tumor diagnosis because they can provide more alternative and reliable information for accurate detection and therapy of diseases than single imaging technique. However, most reported conventional imaging agents have not been found to successfully overcome the disadvantages of traditional diagnoses such as sensitivity, spatial resolution, short half-decay time and complexity. Therefore, exploring a multifunctional nanocomposite with the combination of their individual modality characteristics has great impact on preoperative imaging and intraoperative diagnosis of cancer. In our study, mesoporous silica gadolinium-loaded gap-enhanced Raman tags (Gd-GERTs) specifically for preoperative and intraoperative imaging are designed and their imaging capability and biosafety are examined. They exhibit strong attenuation property for computed X-ray tomography (CT) imaging, high T-1 relaxivity for magnetic resonance (MR) imaging capability and surface-enhanced Raman spectroscopy (SERS) signal with good dispersity and stability, which presents CT/MR/SERS multi-mode imaging performance of the tumor of mice within a given time. Furthermore, in vivo biodistribution and long-term toxicity studies reveal that the Gd-GERTs have good biocompatibility and bio-safety. Therefore, Gd-GERTs are of great potential as a multifunctional nanoplatform for accurate preoperative CT/MRI diagnosis and intraoperative Raman imaging-guide resection of cancers.Statement of SignificanceRecent advances in molecular imaging technology have provided a myriad of opportunities to prepare various nanomaterials for accurate diagnosis and response evaluation of cancer via different imaging modalities. However, single bioimaging modality is still challenging to overcome the issues such as sensitivity, spatial resolution, imaging speed and complexity for clinicians. In this work, we designed a kind of unique multifunctional nanoprobes with computed X-ray tomography/magnetic resonance/surface-enhanced Raman spectroscopy (CT/MR/SERS) triple-modal imaging capabilities. Multifunctional nanotags offer the capabilities of preoperative noninvasive CT/MR imaging for identification of tumors as well as intraoperative real-time SERS imaging for guidance of complete resection of tumors. These multifunctional nanoprobes show critical clinical significance on the improvement of tumor diagnosis and therapy. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.