TOMOGRAPHIC MEASUREMENT OF LOCAL CEREBRAL GLUCOSE METABOLIC-RATE IN HUMANS WITH (F-18)2-FLUORO-2-DEOXY-D-GLUCOSE - VALIDATION OF METHOD
TOMOGRAPHIC MEASUREMENT OF LOCAL CEREBRAL GLUCOSE METABOLIC-RATE IN HUMANS WITH (F-18)2-FLUORO-2-DEOXY-D-GLUCOSE - VALIDATION OF METHOD
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DOI：
10.1002/ana.410060502
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发表时间：
1979-01-01
影响因子：
11.2
通讯作者：
KUHL, DE
中科院分区：
文献类型：
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作者：
PHELPS, ME;HUANG, SC;KUHL, DE
将示踪技术、定量放射自显影和组织计数模型与正电子计算机断层扫描(PCT)和(F-18)2-氟-2-脱氧-D-葡萄糖(FDG)相结合，用于测量人脑局部葡萄糖代谢率(LCMRGlc)。建立了一个包括FDG-6-PO4水解物为FDG的三室模型，用于测定动力学常数和计算LCMRGlc。我们的模型是Sokoloff等人开发的模型的扩展。虽然FDG-6-PO4的水解量很小，但被发现是显著的。一个PCT系统，ECAT，被用来确定该模型在人体内的速率常数、集总常数和稳定性。数据表明，人类大脑中的FDG-6-PO4在大约90分钟内升高，进入平台期，然后缓慢下降。10分钟后，脑血FDG活性水平被发现是组织活动的一小部分。测定前体池周转率、分布体积和红细胞-血浆浓度比。在5小时内，LCMRGlc测量(∼2cm2区域)的重复性(精度)为±5.5%。验证了用静脉采血代替动脉采血的可行性。
Tracer techniques and quantitative autoradiographic and tissue counting models for measuremnt of metabolic rates were combined with positron computed tomography (PCT) and (F-18) 2-fluoro-2-deoxy-D-glucose (FDG) for the measurement of local cerebral metabolic rate for glucose (LCMRGlc) in humans. A three-compartment model, which incorporates hydrolysis of FDG-6-PO 4 to FDG, was developed for the measure of kinetic constants and calculation of LCMRGlc. Our model is an extension of that developed by Sokoloff et al. Although small, hydrolysis of FDG-6-PO 4 was found to be significant. A PCT system, the ECAT, was used to determine the rate constants, lumped constant, and stability of the model in human beings. The data indicate that cerebral FDG-6-PO 4 in humans increases for about 90 minutes, plateaus, and then slowly decreases. After 10 minutes, cerebral blood FDG activity levels were found to be a minor fraction of tissue activity. Precursor pool turnover rate, distribution volumes, and red blood cell-plasma concentration ratios were determined. Reproducibility (precision) of LCMRGlc measurements (∼ 2 cm 2 regions) was±5.5% over a 5-hour period. The replacement of arterial blood sampling with venous sampling was validated.