Leptin levels are appropriate for body mass index in older men who experience involuntary weight loss.
Leptin levels are appropriate for body mass index in older men who experience involuntary weight loss.
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瘦素水平适合经历非自愿体重减轻的老年男性的体重指数。
DOI：
10.1046/j.1532-5415.2002.50414.x
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发表时间：
2002
影响因子：
6.3
通讯作者：
Weigle,DavidS
中科院分区：
文献类型：
--
作者：
Yukawa,Michi;McCormick,WayneC;Rajan,Suparna;Matsumoto,AlvinM;Wallace,JefferyI;Pearlman,RobertA;Weigle,DavidS
目的：确定瘦素与老年人非故意体重减轻之间的关系。设计：2年以上的前瞻性队列研究。地点：大学附属退伍军人事务医疗中心。参与者：受试者为105名65岁及以上的社区居住男性退伍军人，他们参加了1986年至1989年在退伍军人事务普吉特海湾医疗保健系统进行的营养和健康前瞻性队列研究。储存的血液标本进行分析瘦素，胰岛素，葡萄糖，C反应蛋白，性激素结合球蛋白，和testosterone level.Results：超过2年，75名男性体重稳定（体重减轻<4%的基线）和30名男性有无意的体重减轻（体重减轻>4%的基线）。两组的基线体重指数（BMI）和瘦素水平无统计学差异。在体重稳定和体重减轻的受试者中，瘦素水平与各时间点的BMI呈正相关。此外，在多元回归分析中，1年内瘦素变化与BMI变化之间存在显著相关性（第一年后r=.436，P < .001;第二年后r =.630，P =.027hLC13）。结论：与年轻人一样，血浆瘦素水平与BMI成正比，老年人瘦素水平的变化准确反映了BMI的变化。在2年的随访中，空腹瘦素水平不能预测非自愿体重减轻。
OBJECTIVES:To determine the relationship between leptin and unintentional weight loss in older adults.DESIGN:Prospective cohort study over 2 years.SETTING:University‐affiliated Veterans Affairs Medical Center.PARTICIPANTS:The subjects were 105 community‐dwelling male veterans aged 65 and older who had participated in a prospective cohort study on nutrition and health conducted at the Veterans Affairs Puget Sound Health Care System from 1986 to 1989.MEASUREMENTS:Anthropometric data and fasting blood specimens were collected at baseline and annually for the subsequent 2 years. Stored blood specimens were analyzed for leptin, insulin, glucose, C‐reactive protein, sex hormone binding globulin, and testosterone levels.RESULTS:Over 2 years, 75 men were weight stable (weight loss <4% of baseline) and 30 men had unintentional weight loss (weight loss>4% of baseline). The baseline body mass index (BMI) and leptin levels for the two groups were not statistically different. Positive correlations existed between leptin level and BMI at each time point for weight‐stable and weight‐loss subjects. Furthermore, a significant relationship existed between changes in leptin and changes in BMI over 1 year in multiple regression analysis (r= .436,P< .001 after the first year; andr= .630,P= .027 after the second year).CONCLUSIONS:Like in younger adults, plasma leptin levels remained proportional to BMI, and changes in BMI were accurately reflected by changes in leptin levels in older individuals. Fasting leptin levels did not predict involuntary weight loss over 2 years of follow‐up.