Biodegradable Elastomeric Networks: Highly Efficient Cross-Linking of Poly(trimethylene carbonate) by Gamma Irradiation in the Presence of Pentaerythritol Triacrylate
Biodegradable Elastomeric Networks: Highly Efficient Cross-Linking of Poly(trimethylene carbonate) by Gamma Irradiation in the Presence of Pentaerythritol Triacrylate
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DOI：
10.1021/bm1007234
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发表时间：
2010-10-01
影响因子：
6.2
通讯作者：
Grijpma, Dirk W.
中科院分区：
文献类型：
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作者：
Bat, Erhan;Feijen, Jan;Grijpma, Dirk W.
在季戊四醇三丙烯酸酯（PETA）存在下，通过γ辐照线性聚合物，有效地形成了可生物降解的弹性体聚（三亚甲基碳酸酯）（PTMC）网络。研究了含（0.1.5wt%.）PETA作为交联助剂进行了评价。凝胶含量和网络密度随着PETA含量、辐照剂量和聚合物初始分子量的增加而增加。在25 kGy的剂量下，可以获得凝胶分数高达0.96的网络。该网络是无细胞毒性的，具有低于10.7 MPa的弹性模量和高达37.7 MPa的高拉伸强度。PETA的加入还显著改善了抗蠕变性和抗撕裂扩展性，导致永久变形值低至0.9%应变，撕裂强度高达9.3 +/- 2.0 N/mm。此外，网络的酶侵蚀速率可从12.0 +/- 2.9 μ m/天降低至3.0 +/- 1.6 μ m/天。这些可生物降解的弹性体PTMC网络可用于广泛的医疗应用。
Biodegradable elastomeric poly(trimethylene carbonate) (PTMC) networks were efficiently formed by gamma irradiating the linear polymer in the presence of pentaerythritol triacrylate (PETA). The properties of networks formed upon irradiation of PTMC films containing (0.1.5 wt %.) PETA as cross-linking aid were evaluated. The gel contents and network densities increased with increasing PETA contents, irradiation dose, and initial polymer molecular weight. At a dose of 25 kGy, networks with gel fractions up to 0.96 could be obtained. The networks were noncytotoxic had elastic moduli below 10.7 MPa and high tensile strengths of up to 37.7 MPa. The incorporation of PETA also improved the resistance to creep and to tear propagation significantly, resulting in permanent set values that were as low as 0.9% strain and tear strengths up to 9.3 +/- 2.0 N/mm. Furthermore, the enzymatic erosion rates of the networks could be decreased from 12.0 +/- 2.9 to 3.0 +/- 1.6 mu m/day. These biodegradable elostomeric PTMC networks may be utilized in a broad range of medical applications.