Up-regulation of HIV-1 transduction in nondividing cells by double-strand DNA break-inducing agents.
Up-regulation of HIV-1 transduction in nondividing cells by double-strand DNA break-inducing agents.
复制标题
双链 DNA 断裂诱导剂上调非分裂细胞中 HIV-1 转导。
DOI：
10.1007/s10529-010-0449-8
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发表时间：
2011
影响因子：
2.7
通讯作者：
Daniel,René
中科院分区：
文献类型：
--
作者：
Smith,JohannaA;Daniel,René
有效的HIV-1转导依赖于许多细胞辅因子。细胞双链DNA断裂（DSB）修复蛋白已被提出，由我们自己和其他人，需要有效的HIV-1转导。这些DNA修复蛋白的表达和/或活性可以通过将DSB引入宿主细胞基因组中来诱导。HIV-1的转导被上调的治疗与DSB诱导剂在药物逮捕的细胞和分化的神经元细胞。所提出的数据支持DSB修复蛋白参与逆转录病毒生命周期的早期步骤的假设。
Efficient HIV-1 transduction depends on a number of cellular co-factors. Cellular double-strand DNA break (DSB) repair proteins have been proposed, by ourselves and others, to be required for efficient HIV-1 transduction. Expression and/or activity of these DNA repair proteins can be induced by the introduction of DSBs into the host cell genome. HIV-1 transduction was up-regulated by treatment with DSB-inducing agents in both drug-arrested cells and differentiated neuronal cells. The presented data support the hypothesis that DSB repair proteins are involved in the early steps of the retroviral life-cycle.