Bone Repair Using a Hybrid Scaffold of Self-Assembling Peptide PuraMatrix and Polyetheretherketone Cage in Rats
Bone Repair Using a Hybrid Scaffold of Self-Assembling Peptide PuraMatrix and Polyetheretherketone Cage in Rats
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DOI：
10.3727/096368910x508906
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发表时间：
2010-01-01
影响因子：
3.3
通讯作者：
Ozaki, Toshifumi
中科院分区：
文献类型：
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作者：
Nakahara, Hiroyuki;Misawa, Haruo;Ozaki, Toshifumi
自组装肽支架（SAPS）具有良好的骨传导性能。然而，SAPS的强度太弱，实际上不能将其用于临床骨再生。因此，我们已经产生了一种混合支架系统，该系统涉及用具有高强度的聚醚醚酮（PEEK）制造笼，用SAPS填充该笼的内部，然后将该混合支架移植到大鼠股骨中的骨缺损。28天后，软X线片和组织学评估显示，在植入带SAPS的PEEK椎间融合器的缺损中清楚观察到良好的新骨形成，但仅在PEEK椎间融合器中观察不到。PEEK椎间融合器保持内部SAPS的形式和骨传导能力，SAPS促进PEEK内部的骨形成;因此，两者分别负责强度和骨再生。目前的研究表明，混合支架由PEEK笼和SAPS可以是有用的工具，用于再生的承重骨，基于这样的想法，它应该是可能的，开发理想的骨填充材料结合人工骨的强度与骨再生和骨传导性能的SAPS。
Self-assembling peptide scaffold (SAPS) is well known to have very good bone conduction properties. However, the intensity of SAPS is too weak to actually use it for a clinical bone regeneration. Therefore, we have produced a hybrid scaffold system that involves fabricating a cage from polyetheretherketone (PEEK) that has high intensity, filling the interior of this cage with SAPS, and then transplanted this hybrid scaffold to bone defects in rat femurs. After 28 days, soft X-ray radiographs and histological assessment revealed that good new bone formation was clearly observed in the defects transplanted the PEEK cage with SAPS, but not in the PEEK cage only. The PEEK cage maintained a form and osteoconduction ability of internal SAPS, and SAPS promoted bone formation inside the PEEK; therefore, each was in charge of intensity and bone regeneration separately. The present study suggests that hybrid scaffolds made from PEEK cages and SAPS can be useful tools for the regeneration of load-bearing bones, based on the idea that it should be possible to develop ideal bone filler materials by combining the strength of artificial bone with the bone regeneration and bone conduction properties of SAPS.