The clinical appearance of the lamina cribrosa as a function of the extent of glaucomatous optic nerve damage.
The clinical appearance of the lamina cribrosa as a function of the extent of glaucomatous optic nerve damage.
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DOI：
10.1016/s0161-6420(88)33219-7
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发表时间：
1988
期刊：
影响因子：
13.7
通讯作者：
Kevin M. Miller;H. A. Quigley
中科院分区：
文献类型：
--
作者：
Kevin M. Miller;H. A. Quigley
作者评价了52例青光眼患者的87只眼睛中筛板表面上最大临床可见孔的形状，发现孔形状随青光眼视神经乳头损伤程度的变化而明显进展。轻度视野丧失的眼睛以小而圆的毛孔为主，中度视野丧失的眼睛以椭圆形毛孔多见，晚期视野丧失的眼睛以条纹状或狭缝状毛孔最常见。如果筛板的孔随着青光眼性视神经萎缩的增加而延长，并且如果大孔径与压力相关轴突损伤的风险增加相关，则神经节细胞萎缩的阈值可能随着视神经损伤的进展而下降。
The authors evaluated the shapes of the largest clinically visible pores on the surface of the lamina cribrosa in 87 eyes of 52 glaucoma patients and found an apparent progression in pore shape as a function of the extent of glaucomatous optic nerve head damage. Small, round pores predominated in eyes with mild field loss, oval pores were more common in eyes with moderate field loss, and striate or slit-shaped pores were most frequent in eyes with advanced field loss. If the pores of the lamina cribrosa elongate as a function of increasing glaucomatous optic atrophy, and if large pore size is associated with an increased risk for pressure-related axonal damage, then the threshold for ganglion cell atrophy may drop as the damage to the optic nerve progresses.