QSTM1 and GSTT1 polymorphisms and the risk of prostate cancer on a Caribbean population of African descent
QSTM1 and GSTT1 polymorphisms and the risk of prostate cancer on a Caribbean population of African descent
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DOI：
10.1016/j.urology.2007.02.039
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发表时间：
2007-06-01
期刊：
影响因子：
2.1
通讯作者：
Multigner, Luc
中科院分区：
文献类型：
--
作者：
Mallick, Stephane;Romana, Marc;Multigner, Luc
Objectives To investigate whether the glutathione S-transferase polymorphisms GSTM1 and/or GSTT1 contribute to prostate cancer risk in a Caribbean population of African descent in Guadeloupe.Methods We performed a hospital-based case-control study with 134 prostate cancer patients and 134 cancer-free, age-matched control subjects. Epidemiologic data were collected using a standard questionnaire. Logistic regression was used to estimate odds ratios (ORs) and compute confidence intervals (Cls). Genotypes were determined by multiplex polymerase chain reaction.Results The frequency of the GSTM1-positive genotype was 81% in patients and 73% in control Subjects, with an adjusted OR of 1.4 (95% CI 0.7 to 2.5). The frequency of the GSTT1-positive genotype was 78% in patients and 63% in control subjects, with an adjusted OR of 2.6 (95% CI 1.4 to 4.9).Conclusions A functional GSTT1 polymorphism may be associated with prostate cancer susceptibility in a Caribbean Population of African descent.
