Genetic study of lymphoma induction by AKR mink cell focus-inducing virus in AKR x NFS crosses.
Genetic study of lymphoma induction by AKR mink cell focus-inducing virus in AKR x NFS crosses.
复制标题
AKR Mink细胞诱导病毒在AKR X NFS杂交中诱导淋巴瘤的遗传研究。
DOI：
10.1084/jem.154.2.450
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发表时间：
1981-08-01
影响因子：
15.3
通讯作者：
Rowe, W P
中科院分区：
文献类型：
--
作者：
Cloyd, M W;Hartley, J W;Rowe, W P
水貂细胞灶诱导（MCF）-247病毒，最初从AKR胸腺瘤中分离，在AKR小鼠中是淋巴瘤原性的，但在嗜亲性病毒阴性NFS小鼠品系中不是。在这两个品系之间的遗传杂交体中，对AKR-247 MCF病毒诱导淋巴瘤的敏感性分析表明，在哺乳期接种的F1小鼠一致敏感，而在断奶期接种的F1小鼠通常具有抗性。在NFS回交小鼠接种的哺乳期，遗传和表达内源性嗜亲性病毒从AKR是一个重要的相关性复制的MCF病毒和随后的发展淋巴瘤。然而，三分之一的小鼠表达亲嗜性病毒和复制接种的MCF病毒没有发展淋巴瘤。结果表明，可能涉及影响淋巴瘤发展的另一个基因，并且从AKR遗传两个病毒诱导位点的小鼠比仅遗传一个的小鼠更易感。这些研究结果表明，亲嗜性病毒感染在AKR小鼠自发性胸腺瘤发生中的因果作用不仅涉及致白血病MCF病毒的产生，而且还涉及建立对它们生长的宽容。
The mink cell focus-inducing (MCF)-247 virus, originally isolated from an AKR thymoma, is lymphomagenic in AKR mice but not in the ecotropic virus-negative NFS mouse strain. Analysis of sensitivity to lymphoma- induction by AKR-247 MCF virus in genetic hybrids between these two strains showed that F1 mice inoculated as sucklings were uniformly sensitive, whereas those inoculated as weanlings were generally resistant. In NFS backcross mice inoculated as sucklings, inheritance and expression of endogenous ecotropic virus from AKR was an essential correlate of replication of MCF virus and subsequent development of lymphoma. However, one-third of the mice expressing ecotropic virus and replicating the inoculated MCF virus did not develop lymphoma. The results suggested that an additional gene that influenced development of lymphoma may be involved, and that mice inheriting both virus- inducing loci from AKR were more susceptible than those inheriting only one. These findings indicate that the causal role of ecotropic virus infection in spontaneous thymomagenesis in AKR mice involves not only the generation of leukemogenic MCF viruses but also the establishment of permissiveness for their growth.