GENDER DIFFERENCES IN COUNTERREGULATION TO HYPOGLYCEMIA
GENDER DIFFERENCES IN COUNTERREGULATION TO HYPOGLYCEMIA
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DOI：
10.1007/bf00402284
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发表时间：
1993-05-01
期刊：
影响因子：
8.2
通讯作者：
MACDONALD, IA
中科院分区：
文献类型：
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作者：
AMIEL, SA;MARAN, A;MACDONALD, IA
为了研究性别对儿茶酚胺对低血糖反应的影响，对14名健康男性和17名女性进行了单步正血糖-低血糖钳夹试验。女性的肾上腺素反应降低44%(p<；0.01)，去甲肾上腺素反应降低17%(p=0.08)。小剂量静脉注射胰岛素(0.3mU·kg-1。M in-1)，7名男性和7名女性的血糖下降和逆调节有不同的过程(p<；0.001)，具有不同的葡萄糖动力学。在男性中，内源性葡萄糖输出迅速恢复到超过基础水平；在女性中，内源性葡萄糖输出的抑制时间更长，从未超过基础水平(p<；0，05)。外周葡萄糖摄取仅在男性中被刺激。在这次挑战中，急性葡萄糖抵消调节的激素(儿茶酚胺和高血糖素)在性别之间没有差异，女性的儿茶酚胺反应是由血糖的持续下降支持的。这些结果表明：1)女性对中度控制的低血糖的儿茶酚胺反应减弱，2)男性的外周胰岛素敏感性高于女性，但女性的肝脏对胰岛素的敏感性可能更高。
To investigate the effect of gender on catecholamine responses to hypoglycaemia, single-step euglycaemic-hypoglycaemic clamps have been performed in 14 healthy men and 17 women. Adrenaline responses were 44 % lower in females (p < 0.01) and noradrenaline 17% lower (p = 0.08). In response to low-dose intravenous insulin infusion (0.3 mU - kg-1 . min-1), plasma glucose fall and counterregulation in seven men and seven women had a different course (p < 0.001), with different glucose kinetics. In men, endogenous glucose output recovered quickly to levels that exceeded basal; in women suppression of endogenous glucose output was more prolonged, without rates ever exceeding basal (p < 0,05). Peripheral glucose uptake was stimulated in men only. The hormones of acute glucose counterregulation (catecholamines and glucagon) did not differ between the sexes during this challenge, the catecholamine response in the women being supported by the continuous fall in plasma glucose. These results suggest that: 1) catecholamine responses to moderately controlled hypoglycaemia are diminished in women, and 2) peripheral insulin sensitivity in men is enhanced over that of women but hepatic sensitivity to insulin may be greater in women.