Role of Estrogens in the Regulation of Liver Lipid Metabolism.
Role of Estrogens in the Regulation of Liver Lipid Metabolism.
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DOI：
10.1007/978-3-319-70178-3_12
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发表时间：
2017
影响因子：
--
通讯作者：
Stafford JM
中科院分区：
文献类型：
--
作者：
Palmisano BT;Zhu L;Stafford JM
在绝经前，相对于男性，女性免受与肥胖相关的动脉粥样硬化性心脏病的影响。性激素被认为是区分这种风险的一种机制。本文就绝经后内源性性激素及激素治疗方法如何调节脂肪酸、甘油三酯和胆固醇代谢影响心血管风险的相关文献进行综述。雌激素信号通路在脂质代谢方面的重要调节功能部分被绝经后妇女激素治疗的临床试验所掩盖，这是由于不同的制剂、递送途径以及与孕激素的配对。口服激素治疗与几种雌激素制剂增加极低密度脂蛋白甘油三酯生产。孕激素通过刺激人类和动物的VLDL清除来对抗这种效应。经皮雌二醇制剂不增加VLDL的产生或血清甘油三酯。动脉粥样硬化性心脏病风险的性别差异的许多方面受到肌肉、脂肪和肝脏中雌激素分布作用的影响。在人体中，17β雌二醇（E2）是主要的循环雌激素，并通过雌激素受体α（ERα）、雌激素受体β（ER β）和G蛋白偶联雌激素受体（GPER）发出信号。超过1000个人类肝脏基因在其表达中显示出性别偏见，并且顶级生物学途径是脂质代谢和与心血管疾病相关的基因。这些基因中的许多根据小鼠的发情周期而显示变异。未来的发展方向可能依赖于将雌激素靶向特定组织或信号通路的特定方面，以概括绝经后治疗性绝经前的保护生理学。
Before menopause, women are protected from atherosclerotic heart disease associated with obesity relative to men. Sex hormones have been proposed as a mechanism that differentiates this risk. In this review, we discuss the literature around how the endogenous sex hormones and hormone treatment approaches after menopause regulate fatty acid, triglyceride and cholesterol metabolism to influence cardiovascular risk. The important regulatory functions of estrogen signaling pathways with regard to lipid metabolism have been in part obscured by clinical trials with hormone treatment of women after menopause, due to different formulations, routes of delivery, and pairings with progestins. Oral hormone treatment with several estrogen preparations increase VLDL triglyceride production. Progestins oppose this effect by stimulating VLDL clearance in both humans and animals. Transdermal estradiol preparations do not increase VLDL production or serum triglycerides. Many aspects of sex-differences in atherosclerotic heart disease risk are influenced by the distributed actions of estrogens in muscle, adipose and liver. In humans, 17β estradiol (E2) is the predominant circulating estrogen, and signals through Estrogen Receptor alpha (ERα), Estrogen Receptor beta (ER β) and G-protein coupled Estrogen Receptor (GPER). Over 1000 human liver genes display a sex-bias in their expression, and the top biological pathways are in lipid metabolism and genes related to cardiovascular disease. Many of these genes display variation depending on estrus cycling in the mouse. Future directions will likely rely on targeting estrogens to specific tissues, or specific aspects of the signaling pathways in order to recapitulate the protective physiology of pre-menopause therapeutically after menopause.
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影响因子：
2.8
作者：
Cote, I.;Yasari, S.;Lavoie, J-M.
通讯作者：
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影响因子：
15.9
作者：
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影响因子：
8.2
作者：
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作者：
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Boon, Wah Chin
DOI：
10.1016/j.jsbmb.2009.04.008
发表时间：
2009-08-01
影响因子：
4.1
作者：
Badeau, Robert M.;Metso, Jari;Jauhiainen, Matti
通讯作者：
Jauhiainen, Matti