Optimized acquisition time and image sampling for dynamic SPECT of Tl-201
Optimized acquisition time and image sampling for dynamic SPECT of Tl-201
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DOI：
10.1109/42.712123
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发表时间：
1998-06-01
影响因子：
10.6
通讯作者：
Ono, Y
中科院分区：
文献类型：
--
作者：
Lau, CH;Eberl, S;Ono, Y
随着散射和衰减校正算法的最新发展，动态单光子发射计算机断层扫描(SPECT)可以获得潜在的生理参数，示踪剂表现出合适的动力学特性，如Tl-201(T1-201)。提出了一种系统的方法来研究最小数据采集次数和SAM；用蒙特卡罗模拟研究了两种不同的采样方案：1)连续采集30-240分钟的总研究时间，2)连续采集第一个10-45分钟的数据，然后延迟研究大约3小时，根据来自T1-201动力学研究的平均血浆时间活度曲线和速率常数(K-1-K(4))生成具有真实噪声的组织时间活动曲线。比较了全动态采样方案(DYNSS)和最优采样方案(OSS)，发现OSS可以可靠地估计出与DYSS相当的血液Wow相关的K-1和V-d。如果只对K-1感兴趣，30分钟的连续采集就足够了，30分钟动态的分割时段时间表然后3小时的静态研究允许可靠地估计K-1和V-d两者，避免需要长时间(60分钟)的连续动态采集，所开发的方法也应适用于优化乙醚SPECT示踪剂的取样时间表，
With the recent development in scatter and attenuation correction algorithms, dynamic single photon emission computerized tomography (SPECT) cain potentially yield physiological parameters, with tracers exhibiting suitable kinetics such as thallium-201 (T1-201). a systematic way is proposed to investigate the minimum data acquisition times and sam;ling requirements for estimating physiological parameters with quantitative dynamic SPECT.Two different sampling schemes were investigated with Monte Carlo simulations: 1) continuous data collection for total study duration ranging from 30-240 min, 2) Continuous data collection for first 10-45 min followed by a delayed study at approximately 3 h, Tissue time activity curves with realistic noise were generated from a mean plasma time activity curve and rate constants (K-1 - k(4)) derived from T1-201 kinetic studies ire 16 dogs, Full dynamic sampling schedules DynSS) were compared to optimum sampling schedules (OSS).We found that OSS can reliably estimate the blood Wow related K-1 and V-d comparable to DynSS. A 30-min continuous collection was sufficient if only K-1 was of interest, A split session schedule of a 30-min dynamic followed by a static study at 3 h allowed reliable estimation of both K-1 and V-d avoiding the need for a prolonged (>60-min) continuous dynamic acquisition, The methodology developed should also be applicable to optimizing sampling schedules for ether SPECT tracers,