Leading the way: canine models of genomics and disease
Leading the way: canine models of genomics and disease
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DOI：
10.1242/dmm.004358
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发表时间：
2010-01-01
影响因子：
4.3
通讯作者：
Ostrander, Elaine A.
中科院分区：
文献类型：
--
作者：
Shearin, Abigail L.;Ostrander, Elaine A.
近年来，家犬作为一个研究疾病易感性、形态学和行为遗传学的系统，引起了人们的广泛关注。由于狗表现出显着的品种内同质性，再加上惊人的品种间异质性，狗提供了独特的机会，了解哺乳动物的自然变异的遗传基础，其中一部分是疾病的易感性。在这篇综述中，我们强调了狗的独特功能，如人口多样性和品种结构，使其特别适合遗传研究。我们强调了在理解狗基因组结构方面的最新进展，这将该系统推到了选择疾病基因研究系统时考虑的最前沿。使用狗进行遗传学研究最显著的好处是，狗与人类有许多相同的疾病，频率相似，并且通常涉及相同的遗传因素。我们讨论了两种方法定位疾病基因的狗，并提供正在进行的研究的例子。
In recent years Canis familiaris, the domestic dog, has drawn considerable attention as a system in which to investigate the genetics of disease susceptibility, morphology and behavior. Because dogs show remarkable intrabreed homogeneity, coupled with striking interbreed heterogeneity, the dog offers unique opportunities to understand the genetic underpinnings of natural variation in mammals, a portion of which is disease susceptibility. In this review, we highlight the unique features of the dog, such as population diversity and breed structure, that make it particularly amenable to genetic studies. We highlight recent advances in understanding the architecture of the dog genome, which propel the system to the forefront of consideration when selecting a system for disease gene studies. The most notable benefit of using the dog for genetic studies is that dogs get many of the same diseases as humans, with a similar frequency, and the same genetic factors are often involved. We discuss two approaches for localizing disease genes in the dog and provide examples of ongoing studies.