1.2 MV/cm pulsed electric fields promote transthyretin aggregate degradation
1.2 MV/cm pulsed electric fields promote transthyretin aggregate degradation
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DOI：
10.1038/s41598-020-68681-0
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发表时间：
2020-07-20
影响因子：
4.6
通讯作者：
Katsuki, Sunao
中科院分区：
文献类型：
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作者：
Urabe, Gen;Sato, Takashi;Katsuki, Sunao
关于高压电场对蛋白质的影响已经进行了大量的理论研究，但很少有实验证据。为了获得淀粉样蛋白分解理论的实验数据，我们将甲状腺素运载蛋白聚集体暴露于1，000 ns 1.26 MV/cm脉冲电场（PEFs）以促进甲状腺素运载蛋白降解。该过程没有产生pH值的变化，并且所产生的温度升高是
Numerous theoretical studies have been conducted on the effects of high-voltage electric fields on proteins, but few have produced experimental evidence. To acquire experimental data for the amyloid disassemble theory, we exposed transthyretin aggregates to 1,000 ns 1.26 MV/cm pulsed electric fields (PEFs) to promote transthyretin degradation. The process produced no changes in pH, and the resulting temperature increases were