The osteon: the micromechanical unit of compact bone
The osteon: the micromechanical unit of compact bone
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DOI：
10.2741/4003
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发表时间：
2012-01-01
影响因子：
3.1
通讯作者：
Roe, Allison K.
中科院分区：
文献类型：
--
作者：
Ascenzi, Maria-Grazia;Roe, Allison K.
人类骨骼中继骨的研究技术使其生物组成的建立和力学性能的量化成为可能。此外，通过当前研究技术产生的数据有助于研究骨在正常和病理条件下的意义，包括通过多尺度建模来构建虚拟骨的逼真模型，适用于从骨科挑战到内分泌疾病的应用。理解骨元的生物力学功能需要澄清形成、维持和重塑骨元并影响其力学功能的分子细胞过程。反过来，机械功能影响骨细胞的生物学特性。回顾过去，骨的研究主要集中在解开基本成分的复杂组合，以辨别定义力学行为的主要因素。导致宏观断裂的微观结构环境尚不清楚。基本构件的布置、分布和质量都可能参与断裂风险。最新的结果强调了I型胶原和碳化羟基磷灰石晶体取向的基本作用。
The research techniques available for investigation of secondary osteons in human bone enable establishment of their biological composition and quantification of their mechanical properties. Further, the data generated through current research techniques facilitate studies on the significance of osteons in normal and pathological conditions, including via multi-scale modeling conducted with a view of building realistic models of virtual bone, suitable for applications from orthopaedic challenges to endocrine disorders. The understanding of the biomechanical function of the osteon requires clarification of the molecular-cellular processes that form, maintain and remodel the osteon and affect the mechanical function. In turn, the mechanical function affects the biology of the osteon. In retrospective, the investigation of osteons has focused on the unraveling of the complex combination of elementary components to discern the major factors that define the mechanical behavior. The micro-structural environment that leads to macroscopic fracture remains unclear. Arrangement, distribution and quality of the elementary components may participate in fracture risk. The latest results underline the fundamental role of the orientation of collagen type I and of carbonated hydroxyapatite crystallites.