Epidural anaesthetic effect of the 8% emulsified isoflurane: a study in rabbits
Epidural anaesthetic effect of the 8% emulsified isoflurane: a study in rabbits
复制标题
硬膜外%20麻醉%20效果%20of%20the%208%%20乳化%20异氟烷:%20a%20study%20in%20rabbits
DOI：
10.1093/bja/aem298
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发表时间：
2008-01-01
影响因子：
9.8
通讯作者：
Wang, Q. -W.
中科院分区：
文献类型：
--
作者：
Chai, Y. -F.;Yang, J.;Wang, Q. -W.
背景研究表明，局部使用挥发性麻醉剂可产生局部麻醉作用，如局部浸润麻醉（大鼠和人类）和脊髓麻醉（犬）。但目前尚未见关于吸入麻醉剂硬膜外麻醉效果的报道。本研究旨在评价8%乳化异氟醚对家兔硬膜外麻醉的效果。将40只家兔随机分为4组，每组10只。根据分组，E-异氟醚组硬膜外注入8%乳化异氟醚（v/v）1 ml，利多卡因组注入1%利多卡因1 ml，伊曲肽组注入30%脂肪乳剂1 ml，NS组注入生理盐水1 ml。在基线和预定的定期间隔评估感觉和运动功能以及意识状态。连续观察2周，观察可能的远期神经系统并发症。E-异氟烷组的感觉阻滞起效时间、运动阻滞起效时间和运动阻滞持续时间[分别为1.4（0.7）、1.6（0.7）和34（10）min]与利多卡因组相似[分别为1.3（0.5）、1.7（0.8）和38（8）min]。感觉阻滞时间E-异氟醚组68（13）min，利多卡因组49（13）min，两组比较差异有统计学意义（P < 0.01）。NS组和Intralidid组均未发生硬膜外麻醉效应。硬膜外给药后，所有家兔均未出现异常意识。在2周的观察期间，所有家兔均未显示任何长期神经功能缺损。本研究表明，硬膜外注射8%乳化异氟烷可产生完全可逆的硬膜外麻醉作用，不会影响家兔的意识水平。
Background. Studies have shown that local use of volatile anaesthetics produce local anaesthetic effects such as local infiltration anaesthesia (in rats and humans) and spinal anaesthesia (in dogs). However, there is still no report on the epidural anaesthetic effect of volatile anaesthetics. The aim of the present study was to evaluate the epidural anaesthetic effect of the 8% emulsified isoflurane in rabbits.Methods. Forty rabbits chronically instrumented with an epidural catheter were randomly divided into four groups of 10 rabbits each. According to group assignment, rabbits received epidural administration of 8% emulsified isoflurane (v/v) 1 ml in the E-isoflurane group, 1% lidocaine 1 ml in the Lidocaine group, 30% lipid emulsion 1 ml in the Itralipid group, or normal saline 1 ml in the NS group. The sensory and motor functions and the state of consciousness were assessed at baseline and at predetermined regular intervals. Then, the rabbits were continuously observed for 2 weeks to examine the possible long-term neurological complications.Results. The sensory blockade onset time, motor blockade onset time, and motor blockade duration in the E-isoflurane group [1.4 (0.7), 1.6 (0.7), and 34 (10) min, respectively] were similar to those in the Lidocaine group [1.3 (0.5), 1.7 (0.8), and 38 (8), min, respectively]. The sensory blockade duration in the E-isoflurane group was longer than that in the Lidocaine group [68 (13) vs 49 (13) min, P < 0.01]. No epidural anaesthetic effects occurred in the NS group and the Intralipid group. None of the rabbits showed an abnormal consciousness after the epidural drug administration. None of the rabbits showed any long-term neurological deficits during a 2 week observation.Conclusions. The present study demonstrates that epidural administration of the 8% emulsified isoflurane produces completely a reversible epidural anaesthetic effect that does not affect the level of consciousness in rabbits.