Origins of metabolic complications in obesity: adipose tissue and free fatty acid trafficking.
Origins of metabolic complications in obesity: adipose tissue and free fatty acid trafficking.
复制标题
肥胖中代谢并发症的起源：脂肪组织和游离脂肪酸运输。
DOI：
10.1097/mco.0b013e32834ad8b6
复制
发表时间：
2011-11
影响因子：
3.1
通讯作者：
Mittendorfer B
中科院分区：
文献类型：
--
作者：
Mittendorfer B
Obesity is associated with a number of serious medical complications that are risk factors for cardiovascular disease (e.g., insulin resistance, dyslipidemia and liver fat accumulation). Alterations in fatty acid trafficking, both between tissues and within cells, represent a key feature in the pathophysiology of the metabolic complications in obese subjects. The ways by which fatty acid “re-routing” may affect metabolic function are summarized in this article. Ectopic fat accumulation (i.e., fat accumulation in non-adipose tissues) appears to be a key feature distinguishing metabolically healthy from metabolically abnormal subjects. This observation has led to the believe that an imbalance in fatty acid trafficking away from adipose tissue towards non-adipose tissues is a primary cause for the development of metabolic alterations in obese subjects. More recently, however, it has become apparent that fatty acid trafficking with within non-adipose tissues cells (i.e., towards storage - in the form of triglycerides - and oxidation) may be equally important in determining risk for development of metabolic disease. The pathophysiology of the metabolic alterations associated with obesity is probably multifactorial within a complex network of coordinated physiological responses. Only through the integration of multiple concepts will it be possible to further our understanding in this area and to help prevent the metabolic alterations associated with obesity.
